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4M5S
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BU of 4m5s by Molmil
Human alphaB crystallin core domain in complex with C-terminal peptide
Descriptor: Alpha-crystallin B chain, SUCCINIC ACID
Authors:Laganowsky, A, Cascio, D, Sawaya, M.R, Eisenberg, D.
Deposit date:2013-08-08
Release date:2014-04-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity.
Proc.Natl.Acad.Sci.USA, 111, 2014
4M5T
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BU of 4m5t by Molmil
Disulfide trapped human alphaB crystallin core domain in complex with C-terminal peptide
Descriptor: Alpha-crystallin B chain, SULFATE ION
Authors:Laganowsky, A, Cascio, D, Hochberg, G, Sawaya, M.R, Benesch, J.L.P, Robinson, C.V, Eisenberg, D.
Deposit date:2013-08-08
Release date:2014-04-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity.
Proc.Natl.Acad.Sci.USA, 111, 2014
6PQ5
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BU of 6pq5 by Molmil
AGAAAA segment 113-118 from human prion
Descriptor: MALONATE ION, Major prion protein
Authors:Apostol, M.I, Sawaya, M.R, Eisenberg, D.
Deposit date:2019-07-08
Release date:2020-04-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.
Nat.Struct.Mol.Biol., 27, 2020
6PQA
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BU of 6pqa by Molmil
GAVVGG segment 119-124 from human prion
Descriptor: Major prion protein
Authors:Apostol, M.I, Sawaya, M.R, Eisenberg, D.
Deposit date:2019-07-08
Release date:2020-04-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.
Nat.Struct.Mol.Biol., 27, 2020
4QXX
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BU of 4qxx by Molmil
Structure of the amyloid forming peptide GNLVS (residues 26-30) from the eosinophil major basic protein (EMBP)
Descriptor: Bone marrow proteoglycan
Authors:Soriaga, A.B, Soragni, A, Sawaya, M.R, Eisenberg, D.
Deposit date:2014-07-22
Release date:2015-03-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.445 Å)
Cite:Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation.
Mol.Cell, 57, 2015
4QX1
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BU of 4qx1 by Molmil
Cry3A Toxin structure obtained by Serial Femtosecond Crystallography from in vivo grown crystals isolated from Bacillus thuringiensis and data processed with the CrystFEL software suite
Descriptor: Pesticidal crystal protein cry3Aa
Authors:Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D.
Deposit date:2014-07-17
Release date:2014-08-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc.Natl.Acad.Sci.USA, 111, 2014
5TXJ
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BU of 5txj by Molmil
Polymorphic form 1 of amyloid-beta derived peptide - IFAEDV
Descriptor: amyloid-beta derived peptide
Authors:Sangwan, S, Sawaya, M.R, Eisenberg, D.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Distal amyloid beta-protein fragments template amyloid assembly.
Protein Sci., 27, 2018
5TXD
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BU of 5txd by Molmil
Structure of amyloid-beta derived peptide - NKGAIF
Descriptor: Amyloid beta A4 protein, PHOSPHATE ION
Authors:Sangwan, S, Sawaya, M.R, Eisenberg, D.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.452 Å)
Cite:Distal amyloid beta-protein fragments template amyloid assembly.
Protein Sci., 27, 2018
5TXH
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BU of 5txh by Molmil
Polymorphic form 2 of amyloid-beta derived peptide - IFAEDV
Descriptor: IFAEDV, ISOPROPYL ALCOHOL
Authors:Sangwan, S, Sawaya, M.R, Eisenberg, D.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Distal amyloid beta-protein fragments template amyloid assembly.
Protein Sci., 27, 2018
4RP7
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BU of 4rp7 by Molmil
Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258)
Descriptor: TIITLE hexapeptide segment from p53, ZINC ION
Authors:Soriaga, A.B, Soragni, A, Eisenberg, D.
Deposit date:2014-10-29
Release date:2016-01-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.576 Å)
Cite:A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Cancer Cell, 29, 2016
4RP6
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BU of 4rp6 by Molmil
Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258)
Descriptor: LTIITLE heptapeptide segment from p53
Authors:Soriaga, A.B, Soragni, A, Eisenberg, D.
Deposit date:2014-10-29
Release date:2016-01-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Cancer Cell, 29, 2016
5WMJ
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BU of 5wmj by Molmil
KVWGSI segment from Superoxide Dismutase 1,residues 30-35
Descriptor: Superoxide dismutase [Cu-Zn], trifluoroacetic acid
Authors:Sangwan, S, Sawaya, M, Eisenberg, D.
Deposit date:2017-07-28
Release date:2018-03-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.
Protein Sci., 27, 2018
4ONK
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BU of 4onk by Molmil
[Leu-5]-Enkephalin mutant - YVVFL
Descriptor: [Leu-5]-Enkephalin mutant - YVVFL
Authors:Sangwan, S, Eisenberg, D, Sawaya, M.R, Do, T.D, Bowers, M.T, Lapointe, N.E, Teplow, D.B, Feinstein, S.C.
Deposit date:2014-01-28
Release date:2014-07-02
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Factors that drive Peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants.
J.Phys.Chem.B, 118, 2014
4OLR
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BU of 4olr by Molmil
[Leu-5]-Enkephalin mutant - YVVFV
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, [Leu-5]-Enkephalin mutant - YVVFV
Authors:Sangwan, S, Eisenberg, D, Sawaya, M.R, Do, T.D, Bowers, M.T, Lapointe, N.E, Teplow, D.B, Feinstein, S.C.
Deposit date:2014-01-24
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Factors that drive Peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants.
J.Phys.Chem.B, 118, 2014
4NIP
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BU of 4nip by Molmil
GVIGIAQ segment 147-153 from Human Superoxide Dismutase
Descriptor: GVTGIAQ segment from Superoxide dismutase [Cu-Zn]
Authors:Sievers, S.A, Sawaya, M.R, Eisenberg, D, Ivanova, M.I.
Deposit date:2013-11-06
Release date:2013-12-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIN
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BU of 4nin by Molmil
DSVISLS segment 101-107 from Human Superoxide Dismutase
Descriptor: DSVISLS segment from Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Sievers, S.A, Sawaya, M.R, Eisenberg, D.
Deposit date:2013-11-06
Release date:2013-12-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.402 Å)
Cite:Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.
Proc.Natl.Acad.Sci.USA, 111, 2014
4QX0
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BU of 4qx0 by Molmil
Cry3A Toxin structure obtained by Serial Femtosecond Crystallography from in vivo grown crystals isolated from Bacillus thuringiensis and data processed with the cctbx.xfel software suite
Descriptor: Pesticidal crystal protein cry3Aa
Authors:Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D.
Deposit date:2014-07-17
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIO
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BU of 4nio by Molmil
GVTGIAQ segment 147-153 from Human Superoxide Dismutase with I149T mutation associated with a familial form of amyotrophic lateral sclerosis
Descriptor: GVTGIAQ segment from Superoxide dismutase [Cu-Zn]
Authors:Sievers, S.A, Sawaya, M.R, Eisenberg, D, Ivanova, M.I.
Deposit date:2013-11-06
Release date:2013-12-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.
Proc.Natl.Acad.Sci.USA, 111, 2014
6AXZ
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BU of 6axz by Molmil
Segment from bank vole prion protein 168-176 QYNNQNNFV
Descriptor: Major prion protein
Authors:Glynn, C, Rodriguez, J.A, Boyer, D.R, Gallagher-Jones, M.
Deposit date:2017-09-07
Release date:2018-01-17
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (0.75 Å)
Cite:Sub-angstrom cryo-EM structure of a prion protofibril reveals a polar clasp.
Nat. Struct. Mol. Biol., 25, 2018
4QX3
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BU of 4qx3 by Molmil
Cry3A Toxin structure obtained by injecting Bacillus thuringiensis cells in an XFEL beam, collecting data by serial femtosecond crystallographic methods and processing data with the CrystFEL software suite
Descriptor: Pesticidal crystal protein cry3Aa
Authors:Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D.
Deposit date:2014-07-17
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc.Natl.Acad.Sci.USA, 111, 2014
4QX2
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BU of 4qx2 by Molmil
Cry3A Toxin structure obtained by injecting Bacillus thuringiensis cells in an XFEL beam, collecting data by serial femtosecond crystallographic methods and processing data with the cctbx.xfel software suite
Descriptor: Pesticidal crystal protein cry3Aa
Authors:Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D.
Deposit date:2014-07-17
Release date:2014-08-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc.Natl.Acad.Sci.USA, 111, 2014
5DLB
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BU of 5dlb by Molmil
Crystal structure of chaperone EspG3 of ESX-3 type VII secretion system from Mycobacterium marinum M
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, GLYCEROL, PLATINUM (II) ION, ...
Authors:Chan, S, Arbing, M.A, Kim, J, Kahng, S, Sawaya, M.R, Eisenberg, D.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-09-04
Release date:2015-09-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
J. Mol. Biol., 431, 2019
5CYU
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BU of 5cyu by Molmil
Structure of the soluble domain of EccB1 from the Mycobacterium smegmatis ESX-1 secretion system.
Descriptor: Conserved membrane protein
Authors:Arbing, M.A, Chan, S, Kahng, S, Kim, J, Eisenberg, D.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-30
Release date:2015-08-12
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16, 2016
6UUR
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BU of 6uur by Molmil
Human prion protein fibril, M129 variant
Descriptor: Major prion protein
Authors:Glynn, C, Sawaya, M.R, Ge, P, Zhou, Z.H, Rodriguez, J.A.
Deposit date:2019-10-31
Release date:2020-04-15
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.
Nat.Struct.Mol.Biol., 27, 2020
1A2W
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BU of 1a2w by Molmil
CRYSTAL STRUCTURE OF A 3D DOMAIN-SWAPPED DIMER OF BOVINE PANCREATIC RIBONUCLEASE A
Descriptor: CHLORIDE ION, RIBONUCLEASE A, SULFATE ION
Authors:Liu, Y, Hart, P.J, Schlunegger, M.P, Eisenberg, D.S.
Deposit date:1998-01-12
Release date:1998-04-29
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of a 3D domain-swapped dimer of RNase A at a 2.1-A resolution.
Proc.Natl.Acad.Sci.USA, 95, 1998

226707

数据于2024-10-30公开中

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