4M5S
Human alphaB crystallin core domain in complex with C-terminal peptide
Summary for 4M5S
Entry DOI | 10.2210/pdb4m5s/pdb |
Related | 4M5T |
Descriptor | Alpha-crystallin B chain, SUCCINIC ACID, ... (4 entities in total) |
Functional Keywords | small heat shock protein, amyloid, chaperone |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P02511 P02511 |
Total number of polymer chains | 2 |
Total formula weight | 11248.65 |
Authors | Laganowsky, A.,Cascio, D.,Sawaya, M.R.,Eisenberg, D. (deposition date: 2013-08-08, release date: 2014-04-09, Last modification date: 2024-02-28) |
Primary citation | Hochberg, G.K.,Ecroyd, H.,Liu, C.,Cox, D.,Cascio, D.,Sawaya, M.R.,Collier, M.P.,Stroud, J.,Carver, J.A.,Baldwin, A.J.,Robinson, C.V.,Eisenberg, D.S.,Benesch, J.L.,Laganowsky, A. The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity. Proc.Natl.Acad.Sci.USA, 111:E1562-E1570, 2014 Cited by PubMed: 24711386DOI: 10.1073/pnas.1322673111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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