4M5T
Disulfide trapped human alphaB crystallin core domain in complex with C-terminal peptide
Summary for 4M5T
Entry DOI | 10.2210/pdb4m5t/pdb |
Related | 4M5S |
Descriptor | Alpha-crystallin B chain, SULFATE ION, ... (4 entities in total) |
Functional Keywords | small heat shock protein, amyloid, chaperone |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 44958.66 |
Authors | Laganowsky, A.,Cascio, D.,Hochberg, G.,Sawaya, M.R.,Benesch, J.L.P.,Robinson, C.V.,Eisenberg, D. (deposition date: 2013-08-08, release date: 2014-04-09, Last modification date: 2019-07-17) |
Primary citation | Hochberg, G.K.,Ecroyd, H.,Liu, C.,Cox, D.,Cascio, D.,Sawaya, M.R.,Collier, M.P.,Stroud, J.,Carver, J.A.,Baldwin, A.J.,Robinson, C.V.,Eisenberg, D.S.,Benesch, J.L.,Laganowsky, A. The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity. Proc.Natl.Acad.Sci.USA, 111:E1562-E1570, 2014 Cited by PubMed: 24711386DOI: 10.1073/pnas.1322673111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report