4M5T

Disulfide trapped human alphaB crystallin core domain in complex with C-terminal peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	LYS82
A	HIS83
C	LYS82
C	HIS83
E	LYS82
E	HIS83
G	HIS83

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 201

Chain	Residue
D	GLU156
E	GLN108
E	ASP109
E	GLU110
C	SER138
C	SER139

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 201

Chain	Residue
D	GLU156
D	THR158

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 201

Chain	Residue
A	ARG69
A	ARG74
A	SER76
E	ARG69
E	ARG74
E	SER76

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 202

Chain	Residue
E	GLY112
G	ARG123

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 201

Chain	Residue
C	LYS150
E	ASP109
E	GLU110
F	ARG157
F	THR158

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 G 201

Chain	Residue
C	ARG69
C	ARG74
C	SER76
G	ARG69
G	ARG74
G	SER76

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 201

Chain	Residue
A	LYS150
H	ARG157
H	THR158

---

site_id	AC9
Number of Residues	39
Details	BINDING SITE FOR CHAIN B OF ALPHA-CRYSTALLIN B CHAIN

Chain	Residue
A	LEU89
A	VAL91
A	LYS92
A	VAL93
A	LEU94
A	PRO130
A	LEU131
A	ILE133
A	THR134
A	SER135
A	SER136
A	LEU137
A	SER138
A	LEU143
A	HOH304
B	HOH201
B	HOH202
B	HOH203
B	HOH204
B	HOH205
B	HOH206
B	HOH207
B	HOH208
E	MET68
E	MET68
E	ARG69
E	LEU70
E	ASP96
E	ASP96
E	ARG123
E	ILE124
E	PRO125
E	ALA126
E	VAL128
E	PRO130
E	HOH301
E	HOH304
E	HOH312
G	HIS111

---

site_id	BC1
Number of Residues	28
Details	BINDING SITE FOR CHAIN D OF ALPHA-CRYSTALLIN B CHAIN

Chain	Residue
G	ARG123
G	ARG149
G	LYS150
G	GLN151
G	VAL152
C	LYS90
C	VAL91
C	LYS92
C	VAL93
C	PRO130
C	LEU131
C	ILE133
C	THR134
C	SER135
C	SER136
C	LEU137
C	SO4201
C	HOH316
D	SO4201
D	HOH301
D	HOH302
D	HOH303
D	HOH304
E	GLU110
G	LYS72
G	ASP96
G	VAL97
G	LYS121

---

site_id	BC2
Number of Residues	29
Details	BINDING SITE FOR CHAIN F OF ALPHA-CRYSTALLIN B CHAIN

Chain	Residue
A	LEU94
A	ASP96
A	VAL97
A	LYS121
A	ARG123
C	LYS72
C	ASP127
C	ARG149
C	LYS150
C	GLN151
C	VAL152
E	VAL91
E	LYS92
E	VAL93
E	LEU94
E	ASP109
E	PRO130
E	LEU131
E	ILE133
E	THR134
E	SER135
E	SER136
E	LEU137
E	LEU143
F	SO4201
F	HOH301
F	HOH302
F	HOH303
F	HOH305

---

site_id	BC3
Number of Residues	22
Details	BINDING SITE FOR CHAIN H OF ALPHA-CRYSTALLIN B CHAIN

Chain	Residue
A	LYS72
A	ARG149
A	LYS150
A	GLN151
A	VAL152
A	HOH303
C	ARG123
G	VAL91
G	LYS92
G	VAL93
G	LEU94
G	PRO130
G	LEU131
G	ILE133
G	SER135
G	SER136
G	LEU137
G	LEU143
G	HOH305
G	HOH314
H	SO4201
H	HOH301

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22890888","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Susceptible to oxidation"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; partial","evidences":[{"source":"PubMed","id":"11369851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22120592","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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