6NLV
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![BU of 6nlv by Molmil](/molmil-images/mine/6nlv) | Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines | Descriptor: | 4-[3-(2,4-difluorophenyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | Authors: | Singh, S, McKenna, R. | Deposit date: | 2019-01-09 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.794 Å) | Cite: | Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer. J.Med.Chem., 64, 2021
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5K0S
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7RI5
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![BU of 7ri5 by Molmil](/molmil-images/mine/7ri5) | Structure of a BAM in MSP1E3D1 nanodiscs at 4 Angstrom resolution | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Wu, R.R, Noinaj, N. | Deposit date: | 2021-07-19 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM. Nat Commun, 12, 2021
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7RJ5
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![BU of 7rj5 by Molmil](/molmil-images/mine/7rj5) | The structure of BAM in complex with EspP at 7 Angstrom resolution | Descriptor: | Maltodextrin-binding protein,Autotransporter outer membrane beta-barrel domain-containing protein chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | Authors: | Wu, R.R, Noinaj, N. | Deposit date: | 2021-07-20 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM. Nat Commun, 12, 2021
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7RI6
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7RI7
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![BU of 7ri7 by Molmil](/molmil-images/mine/7ri7) | The structure of BAM in MSP1D1 nanodiscs | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Wu, R.R, Noinaj, N. | Deposit date: | 2021-07-19 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM. Nat Commun, 12, 2021
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7RI4
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![BU of 7ri4 by Molmil](/molmil-images/mine/7ri4) | Structure of a BAM/EspP(beta9-12) hybrid-barrel intermediate | Descriptor: | EspPbeta9-12, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | Authors: | Wu, R.R, Noinaj, N. | Deposit date: | 2021-07-19 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM. Nat Commun, 12, 2021
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7RI9
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![BU of 7ri9 by Molmil](/molmil-images/mine/7ri9) | The structure of BAM in MSP1E3D1 at 6.9 Angstrom resolution | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Wu, R.R, Noinaj, N. | Deposit date: | 2021-07-19 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM. Nat Commun, 12, 2021
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7RI8
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![BU of 7ri8 by Molmil](/molmil-images/mine/7ri8) | The structure of BAM in MSP2N2 nanodiscs | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Wu, R.R, Noinaj, N. | Deposit date: | 2021-07-19 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM. Nat Commun, 12, 2021
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5K0T
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7RYF
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![BU of 7ryf by Molmil](/molmil-images/mine/7ryf) | A. baumannii Ribosome-TP-6076 complex: P-site tRNA 70S | Descriptor: | (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 16S Ribosomal RNA, 23S ribosomal RNA, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2021-08-25 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii. Mbio, 13, 2022
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5J59
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![BU of 5j59 by Molmil](/molmil-images/mine/5j59) | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1893) | Descriptor: | 5-chloro-N-(2-{[(3,5-dichlorophenyl)methyl]amino}ethyl)-N-methyl-3H-imidazo[4,5-b]pyridin-2-amine, GLYCEROL, METHIONINE, ... | Authors: | Barros-Alvarez, X, Hol, W.G.J. | Deposit date: | 2016-04-01 | Release date: | 2017-01-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem, 124, 2016
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8DMH
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![BU of 8dmh by Molmil](/molmil-images/mine/8dmh) | Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28 | Descriptor: | 18.5C-M28 Fab Heavy Chain, 18.5C-M28 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Moon-Walker, A, Hastie, K.M, Zyla, D.S, Saphire, E.O. | Deposit date: | 2022-07-08 | Release date: | 2023-04-12 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chem Biol, 30, 2023
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8DMI
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![BU of 8dmi by Molmil](/molmil-images/mine/8dmi) | Lymphocytic choriomeningitis virus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein G1, ... | Authors: | Moon-Walker, A, Hastie, K.M, Zyla, D.S, Saphire, E.O. | Deposit date: | 2022-07-08 | Release date: | 2023-04-12 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chem Biol, 30, 2023
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4CAD
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![BU of 4cad by Molmil](/molmil-images/mine/4cad) | Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Kulkarni, K, Manolaridis, I, Dodd, R.B, Cronin, N, Ogasawara, S, Iwata, S, Barford, D. | Deposit date: | 2013-10-08 | Release date: | 2013-11-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism of Farnesylated Caax Protein Processing by the Intramembrane Protease Rce1 Nature, 504, 2013
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7LLQ
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![BU of 7llq by Molmil](/molmil-images/mine/7llq) | Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity | Descriptor: | 1-benzyl-4-methoxybenzene, 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, Leukotriene A-4 hydrolase, ... | Authors: | Lee, K.H, Lee, S.H, Shim, Y.M, Paige, M, Noble, S.M. | Deposit date: | 2021-02-04 | Release date: | 2022-06-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Substrate-dependent modulation of the leukotriene A 4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation. Sci Rep, 12, 2022
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8DNP
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![BU of 8dnp by Molmil](/molmil-images/mine/8dnp) | Human Brain Ferritin Heavy Chain | Descriptor: | FE (III) ION, Ferritin heavy chain | Authors: | Tringides, M.L. | Deposit date: | 2022-07-11 | Release date: | 2022-11-16 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes. Life Sci Alliance, 6, 2023
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8DNU
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![BU of 8dnu by Molmil](/molmil-images/mine/8dnu) | Human Brain Glutamine Synthetase | Descriptor: | Glutamine synthetase, MANGANESE (II) ION | Authors: | Tringides, M.L. | Deposit date: | 2022-07-11 | Release date: | 2022-11-16 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes. Life Sci Alliance, 6, 2023
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8DNO
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8DNS
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![BU of 8dns by Molmil](/molmil-images/mine/8dns) | Human Brain Glyceraldehyde 3-phosphate dehydrogenase | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase | Authors: | Tringides, M.L. | Deposit date: | 2022-07-11 | Release date: | 2022-11-16 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes. Life Sci Alliance, 6, 2023
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8DNM
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![BU of 8dnm by Molmil](/molmil-images/mine/8dnm) | Human Brain Dihydropyrimidinase-related protein 2 | Descriptor: | Dihydropyrimidinase-related protein 2 | Authors: | Tringides, M.L. | Deposit date: | 2022-07-11 | Release date: | 2022-11-16 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes. Life Sci Alliance, 6, 2023
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8DYA
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8JY6
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![BU of 8jy6 by Molmil](/molmil-images/mine/8jy6) | Structure of TbAQP2 in complex with anti-trypanosomatid drug melarsoprol | Descriptor: | Aquaglyceroporin 2, [(4~{R})-2-[4-[[4,6-bis(azanyl)-1,3,5-triazin-2-yl]amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol | Authors: | Chen, W, Wang, C. | Deposit date: | 2023-07-03 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insights into drug transport by an aquaglyceroporin. Nat Commun, 15, 2024
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8JY7
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8JY8
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![BU of 8jy8 by Molmil](/molmil-images/mine/8jy8) | |