8JY8

Structure of TbAQP2 in complex with anti-trypanosomatid drug pentamidine

Summary for 8JY8

Entry DOI	10.2210/pdb8jy8/pdb
EMDB information	36723
Descriptor	Aquaglyceroporin 2, 1,5-BIS(4-AMIDINOPHENOXY)PENTANE (2 entities in total)
Functional Keywords	aquaporin, membrane protein
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	4
Total formula weight	135820.26
Authors	Chen, W.,Wang, C. (deposition date: 2023-07-03, release date: 2024-05-29)
Primary citation	Chen, W.,Zou, R.,Mei, Y.,Li, J.,Xuan, Y.,Cui, B.,Zou, J.,Wang, J.,Lin, S.,Zhang, Z.,Wang, C. Structural insights into drug transport by an aquaglyceroporin. Nat Commun, 15:3985-3985, 2024 Cited by PubMed: 38734677 DOI: 10.1038/s41467-024-48445-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.45 Å)

Structure validation