5J59

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1893)

Summary for 5J59

• Entry DOI: 10.2210/pdb5j59/pdb
• Descriptor: Methionyl-tRNA synthetase, putative, METHIONINE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 123287.43

Authors

Barros-Alvarez, X.,Hol, W.G.J. (deposition date: 2016-04-01, release date: 2017-01-25, Last modification date: 2024-03-06)

• Primary citation: Huang, W.,Zhang, Z.,Barros-Alvarez, X.,Koh, C.Y.,Ranade, R.M.,Gillespie, J.R.,Creason, S.A.,Shibata, S.,Verlinde, C.L.,Hol, W.G.,Buckner, F.S.,Fan, E.; Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.; Eur J Med Chem, 124:1081-1092, 2016; PubMed: 27788467; DOI: 10.1016/j.ejmech.2016.10.024

Experimental method

X-RAY DIFFRACTION (2.4 Å)