8E6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e6s by Molmil](/molmil-images/mine/8e6s) | Human TRPM2 ion channel in 1 mM dADPR and Ca2+ | Descriptor: | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, ... | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
|
|
8E6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e6v by Molmil](/molmil-images/mine/8e6v) | MHR1/2 and NUDT9H of human TRPM2 in 1 mM dADPR (local refinement) | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2, ZINC ION | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
|
|
8E6U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e6u by Molmil](/molmil-images/mine/8e6u) | Human TRPM2 ion channel in 1 mM F-dADPR | Descriptor: | Transient receptor potential cation channel subfamily M member 2, [(2R,3S,5R)-5-(6-amino-8-phenyl-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
|
|
8E6Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e6q by Molmil](/molmil-images/mine/8e6q) | Human TRPM2 ion channel in 1 mM ADPR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
|
|
8E6R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e6r by Molmil](/molmil-images/mine/8e6r) | Human TRPM2 ion channel in 1 mM dADPR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
|
|
8E6T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e6t by Molmil](/molmil-images/mine/8e6t) | Human TRPM2 ion channel in 1 mM BR-ADPR | Descriptor: | (3R,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4,5-trihydroxypentyl [(2S,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name), Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
|
|
6MJ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mj2 by Molmil](/molmil-images/mine/6mj2) | Human TRPM2 ion channel in a calcium- and ADPR-bound state | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (6.36 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
|
|
6MIX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mix by Molmil](/molmil-images/mine/6mix) | Human TRPM2 ion channel in apo state | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
|
|
6MIZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6miz by Molmil](/molmil-images/mine/6miz) | |
2JRT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jrt by Molmil](/molmil-images/mine/2jrt) | NMR solution structure of the protein coded by gene RHOS4_12090 of Rhodobacter sphaeroides. Northeast Structural Genomics target RhR5 | Descriptor: | Uncharacterized protein | Authors: | Wang, L, Chen, C, Nwosu, C, Cunningham, K, Owens, L, Ma, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-28 | Release date: | 2007-08-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the protein coded by gene RHOS4_12090 of Rhodobacter sphaeroides. To be Published
|
|
1Y2M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y2m by Molmil](/molmil-images/mine/1y2m) | Crystal structure of phenylalanine ammonia-lyase from yeast Rhododporidium toruloides | Descriptor: | Phenylalanine ammonia-lyase | Authors: | Wang, L, Gamez, A, Sarkissian, C.N, Straub, M, Patch, M.G, Han, G.W, Scriver, C.R, Stevens, R.C. | Deposit date: | 2004-11-22 | Release date: | 2005-11-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria. Mol.Genet.Metab., 86, 2005
|
|
5KN9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kn9 by Molmil](/molmil-images/mine/5kn9) | MutY N-terminal domain in complex with DNA containing an intrahelical oxoG:A base-pair | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ... | Authors: | Wang, L, Chakravarthy, S, Verdine, G.L. | Deposit date: | 2016-06-27 | Release date: | 2017-02-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J. Biol. Chem., 292, 2017
|
|
5KN8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kn8 by Molmil](/molmil-images/mine/5kn8) | MutY N-terminal domain in complex with undamaged DNA | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ... | Authors: | Wang, L, Chakravarthy, S, Verdine, G.L. | Deposit date: | 2016-06-27 | Release date: | 2017-02-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J. Biol. Chem., 292, 2017
|
|
1ZOK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zok by Molmil](/molmil-images/mine/1zok) | PDZ1 Domain Of Synapse Associated Protein 97 | Descriptor: | Presynaptic protein SAP97 | Authors: | Wang, L, Piserchio, A, Mierke, D.F. | Deposit date: | 2005-05-13 | Release date: | 2005-06-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Characterization of the Intermolecular Interactions of Synapse-associated Protein-97 with the NR2B Subunit of N-Methyl-D-aspartate Receptors. J.Biol.Chem., 280, 2005
|
|
4JR4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4jr4 by Molmil](/molmil-images/mine/4jr4) | Crystal structure of Mtb DsbA (Oxidized) | Descriptor: | Possible conserved membrane or secreted protein, SULFATE ION | Authors: | Wang, L. | Deposit date: | 2013-03-21 | Release date: | 2013-07-17 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. Protein Cell, 4, 2013
|
|
4NSC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nsc by Molmil](/molmil-images/mine/4nsc) | Crystal Structure of CBARA1 in the Apo-form | Descriptor: | Calcium uptake protein 1, mitochondrial | Authors: | Wang, L, Yang, X, Li, S, Shen, Y. | Deposit date: | 2013-11-28 | Release date: | 2014-02-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. Embo J., 33, 2014
|
|
4NSD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nsd by Molmil](/molmil-images/mine/4nsd) | Crystal Structure of CBARA1 in the Ca2+ Binding Form | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Wang, L, Yang, X, Li, S, Shen, Y. | Deposit date: | 2013-11-28 | Release date: | 2014-02-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. Embo J., 33, 2014
|
|
7E1A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7e1a by Molmil](/molmil-images/mine/7e1a) | |
7YR4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yr4 by Molmil](/molmil-images/mine/7yr4) | |
8UUK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uuk by Molmil](/molmil-images/mine/8uuk) | Pendrin in apo | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, Lauryl Maltose Neopentyl Glycol, ... | Authors: | Wang, L, Hoang, A, Zhou, M. | Deposit date: | 2023-11-01 | Release date: | 2024-02-07 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism of anion exchange and small-molecule inhibition of pendrin. Nat Commun, 15, 2024
|
|
7Y0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y0o by Molmil](/molmil-images/mine/7y0o) | |
7Y0N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y0n by Molmil](/molmil-images/mine/7y0n) | SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R15-F7, ... | Authors: | Wang, L. | Deposit date: | 2022-06-05 | Release date: | 2023-09-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody To Be Published
|
|
7DV5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dv5 by Molmil](/molmil-images/mine/7dv5) | |
4JR6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4jr6 by Molmil](/molmil-images/mine/4jr6) | Crystal structure of DsbA from Mycobacterium tuberculosis (reduced) | Descriptor: | Possible conserved membrane or secreted protein, SULFATE ION | Authors: | Wang, L. | Deposit date: | 2013-03-21 | Release date: | 2013-07-17 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. Protein Cell, 4, 2013
|
|
6AD3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ad3 by Molmil](/molmil-images/mine/6ad3) | |