8WRB
| Lysophosphatidylserine receptor GPR34-Gi complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Gong, W, Liu, G, Li, X, Wang, Y, Zhang, X. | Deposit date: | 2023-10-13 | Release date: | 2023-11-08 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174. Plos Biol., 21, 2023
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8WCN
| Cryo-EM structure of PAO1-ImcA with GMPCPP | Descriptor: | Diguanylate cyclase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | Authors: | Zhan, X.L, Zhang, K, Wang, C.C, Fan, Q, Tang, X.J, Zhang, X, Wang, K, Fu, Y, Liang, H.H. | Deposit date: | 2023-09-13 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa. Nat Commun, 15, 2024
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5YZG
| The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhan, X, Yan, C, Zhang, X, Lei, J, Shi, Y. | Deposit date: | 2017-12-14 | Release date: | 2018-08-08 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of a human catalytic step I spliceosome Science, 359, 2018
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2QJO
| crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase (NadM) complexed with ADPRP and NAD from Synechocystis sp. | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Bifunctional NMN adenylyltransferase/Nudix hydrolase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Huang, N, Sorci, L, Zhang, X, Brautigan, C, Raffaelli, N, Magni, G, Grishin, N.V, Osterman, A, Zhang, H. | Deposit date: | 2007-07-08 | Release date: | 2008-03-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism. Structure, 16, 2008
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5XEX
| Crystal structure of S.aureus PNPase catalytic domain | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, PYROPHOSPHATE, ... | Authors: | Wang, X, Zhang, X, Zang, J. | Deposit date: | 2017-04-06 | Release date: | 2017-10-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Enolase binds to RnpA in competition with PNPase in Staphylococcus aureus FEBS Lett., 591, 2017
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2QJT
| Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, Nicotinamide-nucleotide adenylyltransferase | Authors: | Huang, N, Sorci, L, Zhang, X, Brautigan, C, Raffaelli, N, Magni, G, Grishin, N.V, Osterman, A, Zhang, H. | Deposit date: | 2007-07-09 | Release date: | 2008-03-04 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism. Structure, 16, 2008
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5YF0
| Crystal structure of CARNMT1 bound to SAM | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Cao, R, Zhang, X, Li, H. | Deposit date: | 2017-09-20 | Release date: | 2018-08-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res., 28, 2018
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8QOT
| Structure of the mu opioid receptor bound to the antagonist nanobody NbE | Descriptor: | Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ... | Authors: | Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M. | Deposit date: | 2023-09-29 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist. Biorxiv, 2023
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4DEN
| Structural insightsinto potent, specific anti-HIV property of actinohivin; Crystal structure of actinohivin in complex with alpha(1-2) mannobiose moiety of high-mannose type glycan of gp120 | Descriptor: | Actinohivin, POTASSIUM ION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose | Authors: | Hoque, M.M, Suzuki, K, Tsunoda, M, Jiang, J, Zhang, F, Takahashi, A, Naomi, O, Zhang, X, Sekiguchi, T, Tanaka, H, Omura, S, Takenaka, A. | Deposit date: | 2012-01-20 | Release date: | 2012-11-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into the specific anti-HIV property of actinohivin: structure of its complex with the alpha(1–2)mannobiose moiety of gp120 Acta Crystallogr.,Sect.D, 68, 2012
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4END
| Crystal structure of anti-HIV actinohivin in complex with alpha-1,2-mannobiose (P 2 21 21 form) | Descriptor: | ACETONITRILE, Actinohivin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose | Authors: | Hoque, M.M, Suzuki, K, Tsunoda, M, Jiang, J, Zhang, F, Takahashi, A, Naomi, O, Zhang, X, Sekiguchi, T, Tanaka, H, Omura, S, Takenaka, A. | Deposit date: | 2012-04-13 | Release date: | 2013-07-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Matured structure of anti-HIV lectin actinohivin in complex with 1,2-mannobiose To be Published
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8FLM
| Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... | Authors: | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | Deposit date: | 2022-12-21 | Release date: | 2023-11-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
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8FLK
| Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2 | Descriptor: | 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP | Authors: | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | Deposit date: | 2022-12-21 | Release date: | 2023-11-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
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8H59
| A fungal MAP kinase in complex with an inhibitor | Descriptor: | Mitogen-activated protein kinase MPS1, ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide | Authors: | Kong, Z, Zhang, X, Wang, D, Liu, J. | Deposit date: | 2022-10-12 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi. Mbio, 14, 2023
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3F8I
| Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group P21 | Descriptor: | 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3', E3 ubiquitin-protein ligase UHRF1 | Authors: | Hashimoto, H, Horton, J.R, Zhang, X, Cheng, X. | Deposit date: | 2008-11-12 | Release date: | 2009-01-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics, 4, 2009
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3FDE
| Mouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1) at 1.4 A resolution | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', ... | Authors: | Hashimoto, H, Horton, J.R, Zhang, X, Cheng, X. | Deposit date: | 2008-11-25 | Release date: | 2009-01-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics, 4, 2009
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3F8J
| Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1) | Descriptor: | 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3', E3 ubiquitin-protein ligase UHRF1, ... | Authors: | Hashimoto, H, Horton, J.R, Zhang, X, Cheng, X. | Deposit date: | 2008-11-12 | Release date: | 2009-01-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics, 4, 2009
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6IRG
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | Authors: | Zhang, J, Chang, S, Zhang, X, Zhu, S. | Deposit date: | 2018-11-12 | Release date: | 2019-01-16 | Last modified: | 2019-06-05 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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6IRA
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8 | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | Authors: | Zhang, J, Chang, S, Zhang, X, Zhu, S. | Deposit date: | 2018-11-12 | Release date: | 2019-01-16 | Last modified: | 2019-06-05 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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6U9I
| Crystal structure of BvnE pinacolase from Penicillium brevicompactum | Descriptor: | BvnE, DI(HYDROXYETHYL)ETHER, GLYCEROL | Authors: | Ye, Y, Du, L, Zhang, X, Newmister, S.A, McCauley, M, Alegre-Requena, J.V, Zhang, W, Mu, S, Minami, A, Fraley, A.E, Adrover-Castellano, M.L, Carney, N, Shende, V.V, Oikawa, H, Kato, H, Tsukamoto, S, Paton, R.S, Williams, R.M, Sherman, D.H, Li, S. | Deposit date: | 2019-09-09 | Release date: | 2020-09-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.777 Å) | Cite: | Fungal-derived brevianamide assembly by a stereoselective semipinacolase. Nat Catal, 3, 2020
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7V1N
| Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI | Descriptor: | Isoform Beta of Tissue factor pathway inhibitor, Toxin B | Authors: | Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L. | Deposit date: | 2021-08-05 | Release date: | 2022-02-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 185, 2022
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6IRH
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class III | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | Authors: | Zhang, J, Chang, S, Zhang, X, Zhu, S. | Deposit date: | 2018-11-12 | Release date: | 2019-01-16 | Last modified: | 2019-06-05 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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6IRF
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | Authors: | Zhang, J, Chang, S, Zhang, X, Zhu, S. | Deposit date: | 2018-11-12 | Release date: | 2019-01-16 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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7SII
| Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53) | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, Stimulator of interferon genes protein, cGAMP | Authors: | Lu, D, Shang, G, Jie, L, Lu, Y, Bai, X.C, Zhang, X. | Deposit date: | 2021-10-14 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Activation of STING by targeting a pocket in the transmembrane domain. Nature, 604, 2022
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6IYA
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8EQB
| FAM46C/BCCIPalpha/Nanobody complex | Descriptor: | Isoform 2 of BRCA2 and CDKN1A-interacting protein, Synthetic nanobody 1, Terminal nucleotidyltransferase 5C | Authors: | Liu, S, Chen, H, Yin, Y, Bai, X, Zhang, X. | Deposit date: | 2022-10-07 | Release date: | 2023-03-15 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold. Sci Adv, 9, 2023
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