4R2S
Wilms Tumor Protein (WT1) Q369P zinc fingers in complex with methylated DNA
Summary for 4R2S
Entry DOI | 10.2210/pdb4r2s/pdb |
Related | 4R2A 4R2C 4R2D 4R2E 4R2P 4R2Q 4R2R |
Descriptor | Wilms tumor protein, isoform 4/CRA_a, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... (6 entities in total) |
Functional Keywords | zinc finger, transcription, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus. Isoform 1: Nucleus speckle. Isoform 4: Nucleus, nucleoplasm: P19544 |
Total number of polymer chains | 3 |
Total formula weight | 18309.67 |
Authors | Hashimoto, H.,Olanrewaju, Y.O.,Zheng, Y.,Wilson, G.G.,Zhang, X.,Cheng, X. (deposition date: 2014-08-12, release date: 2014-10-08, Last modification date: 2023-09-20) |
Primary citation | Hashimoto, H.,Olanrewaju, Y.O.,Zheng, Y.,Wilson, G.G.,Zhang, X.,Cheng, X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes Dev., 28:2304-2313, 2014 Cited by PubMed: 25258363DOI: 10.1101/gad.250746.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.489 Å) |
Structure validation
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