4R2S

Wilms Tumor Protein (WT1) Q369P zinc fingers in complex with methylated DNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS355
A	CYS360
A	HIS373
A	HIS377

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS385
A	CYS388
A	HIS401
A	HIS405

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS418
A	HIS431
A	HIS435
A	CYS413

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 504

Chain	Residue
A	ARG372
A	ARG394
A	SER395
A	ASP396
C	DG4

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 505

Chain	Residue
A	LYS381
A	ARG390
B	DT5

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CdfkdCerrFsrsdplkrHqrr..H

Chain	Residue	Details
A	CYS355-HIS377
A	CYS385-HIS405
A	CYS413-HIS435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Zinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Zinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	22
Details	Region: {"description":"Important for interaction with target DNA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important for interaction with target DNA"}

Chain

Residue

Details

---