4R2P

Wilms Tumor Protein (WT1) zinc fingers in complex with hydroxymethylated DNA

Summary for 4R2P

• Entry DOI: 10.2210/pdb4r2p/pdb
• Related: 4R2A 4R2C 4R2D 4R2E 4R2Q 4R2R 4R2S
• Descriptor: Wilms tumor protein, isoform 4/CRA_a, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5HC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5HC)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... (6 entities in total)
• Functional Keywords: zinc finger, transcription, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus. Isoform 1: Nucleus speckle. Isoform 4: Nucleus, nucleoplasm: P19544
• Total number of polymer chains: 3
• Total formula weight: 18372.68

Authors

Hashimoto, H.,Olanrewaju, Y.O.,Zheng, Y.,Wilson, G.G.,Zhang, X.,Cheng, X. (deposition date: 2014-08-12, release date: 2014-10-08, Last modification date: 2023-09-20)

• Primary citation: Hashimoto, H.,Olanrewaju, Y.O.,Zheng, Y.,Wilson, G.G.,Zhang, X.,Cheng, X.; Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.; Genes Dev., 28:2304-2313, 2014; PubMed: 25258363; DOI: 10.1101/gad.250746.114

Experimental method

X-RAY DIFFRACTION (1.788 Å)