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4R2P

Wilms Tumor Protein (WT1) zinc fingers in complex with hydroxymethylated DNA

Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 501
ChainResidue
ACYS355
ACYS360
AHIS373
AHIS377

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 502
ChainResidue
ACYS385
ACYS388
AHIS401
AHIS405

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 503
ChainResidue
ACYS418
AHIS431
AHIS435
ACYS413

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 504
ChainResidue
ATYR353
AARG366
ASER367
BHOH142
CDC61
CHOH216

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO C 101
ChainResidue
AARG366
AASP368
AARG372
B5HC9
C5HC53
CDG54

Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues23
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CdfkdCerrFsrsdqlkrHqrr..H
ChainResidueDetails
ACYS355-HIS377
ACYS385-HIS405
ACYS413-HIS435

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
ATYR353-HIS377

site_idSWS_FT_FI2
Number of Residues22
DetailsZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
APHE383-HIS405

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Important for interaction with target DNA
ChainResidueDetails
AARG424
AARG430

226707

PDB entries from 2024-10-30

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