4TOR

Crystal structure of Tankyrase 1 with IWR-8

Summary for 4TOR

• Entry DOI: 10.2210/pdb4tor/pdb
• Related: 4TOS
• Descriptor: Tankyrase-1, ZINC ION, 1-[(1-acetyl-5-bromo-1H-indol-6-yl)sulfonyl]-N-ethyl-N-(3-methylphenyl)piperidine-4-carboxamide, ... (5 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 110748.52

Authors

Chen, H.,Zhang, X.,Lum, L.,Chen, C. (deposition date: 2014-06-06, release date: 2015-05-20, Last modification date: 2023-09-27)

• Primary citation: Kulak, O.,Chen, H.,Holohan, B.,Wu, X.,He, H.,Borek, D.,Otwinowski, Z.,Yamaguchi, K.,Garofalo, L.A.,Ma, Z.,Wright, W.,Chen, C.,Shay, J.W.,Zhang, X.,Lum, L.; Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.; Mol.Cell.Biol., 35:2425-2435, 2015; PubMed: 25939383; DOI: 10.1128/MCB.00392-15

Experimental method

X-RAY DIFFRACTION (1.501 Å)