4TOR

Crystal structure of Tankyrase 1 with IWR-8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
B	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
D	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1401

Chain	Residue
A	CYS1234
A	HIS1237
A	CYS1242
A	CYS1245

---

site_id	AC2
Number of Residues	14
Details	binding site for residue IW8 A 1402

Chain	Residue
A	ILE1192
A	GLY1196
A	PHE1197
A	ASP1198
A	HIS1201
A	ILE1212
A	TYR1213
A	TYR1224
A	HOH1570
A	HIS1184
A	GLY1185
A	SER1186
A	PRO1187
A	PHE1188

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 1403

Chain	Residue
A	ASP1115
A	LYS1116

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CL A 1404

Chain	Residue
A	HIS1132
A	ARG1133
A	LYS1220
A	TYR1289
A	HOH1591

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL A 1405

Chain	Residue
A	ARG1149

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL A 1406

Chain	Residue
A	ASN1155
A	ARG1159
A	TYR1301

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CL A 1407

Chain	Residue
A	ALA1191

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 1401

Chain	Residue
B	CYS1234
B	HIS1237
B	CYS1242
B	CYS1245

---

site_id	AC9
Number of Residues	12
Details	binding site for residue IW8 B 1402

Chain	Residue
B	HIS1184
B	SER1186
B	PRO1187
B	PHE1188
B	ALA1191
B	ILE1192
B	GLY1196
B	ASP1198
B	HIS1201
B	ILE1212
B	TYR1213
B	ILE1228

---

site_id	AD1
Number of Residues	3
Details	binding site for residue CL B 1403

Chain	Residue
B	ARG1149
B	LYS1195
B	HOH1567

---

site_id	AD2
Number of Residues	3
Details	binding site for residue CL B 1404

Chain	Residue
B	ASN1155
B	ARG1159
B	TYR1301

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CL B 1405

Chain	Residue
B	HIS1132
B	ARG1133
B	HOH1537
B	HOH1602

---

site_id	AD4
Number of Residues	1
Details	binding site for residue CL B 1406

Chain	Residue
B	ALA1191

---

site_id	AD5
Number of Residues	3
Details	binding site for residue CL B 1407

Chain	Residue
A	HOH1628
B	ALA1271
B	HOH1583

---

site_id	AD6
Number of Residues	4
Details	binding site for residue CL B 1408

Chain	Residue
B	HIS1176
B	HIS1177
B	ASN1178
B	HOH1547

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN C 1401

Chain	Residue
C	CYS1234
C	HIS1237
C	CYS1242
C	CYS1245

---

site_id	AD8
Number of Residues	14
Details	binding site for residue IW8 C 1402

Chain	Residue
C	HIS1184
C	GLY1185
C	SER1186
C	PRO1187
C	PHE1188
C	ALA1191
C	ILE1192
C	GLY1196
C	ASP1198
C	HIS1201
C	ILE1212
C	TYR1213
C	ILE1228
C	ILE1244

---

site_id	AD9
Number of Residues	3
Details	binding site for residue CL C 1403

Chain	Residue
C	ASN1155
C	ARG1159
C	TYR1301

---

site_id	AE1
Number of Residues	4
Details	binding site for residue CL C 1404

Chain	Residue
C	HIS1132
C	ARG1133
C	LYS1220
C	HOH1565

---

site_id	AE2
Number of Residues	2
Details	binding site for residue CL C 1405

Chain	Residue
C	ALA1191
C	HOH1548

---

site_id	AE3
Number of Residues	2
Details	binding site for residue CL C 1406

Chain	Residue
C	ARG1149
C	HOH1504

---

site_id	AE4
Number of Residues	2
Details	binding site for residue CL C 1407

Chain	Residue
D	ASN1155
D	ARG1159

---

site_id	AE5
Number of Residues	4
Details	binding site for residue CL C 1408

Chain	Residue
C	HIS1176
C	HIS1177
C	ASN1178
C	HOH1562

---

site_id	AE6
Number of Residues	4
Details	binding site for residue ZN D 1401

Chain	Residue
D	CYS1234
D	HIS1237
D	CYS1242
D	CYS1245

---

site_id	AE7
Number of Residues	13
Details	binding site for residue IW8 D 1402

Chain	Residue
D	HIS1184
D	SER1186
D	PRO1187
D	PHE1188
D	ALA1191
D	ILE1192
D	GLY1196
D	PHE1197
D	ASP1198
D	HIS1201
D	ILE1212
D	TYR1213
D	TYR1224

---

site_id	AE8
Number of Residues	3
Details	binding site for residue CL D 1403

Chain	Residue
B	ARG1281
D	GLU1123
D	HOH1535

---

site_id	AE9
Number of Residues	5
Details	binding site for residue CL D 1404

Chain	Residue
D	HIS1132
D	ARG1133
D	LYS1220
D	TYR1289
D	HOH1606

---

site_id	AF1
Number of Residues	1
Details	binding site for residue CL D 1405

Chain	Residue
D	ALA1191

---

site_id	AF2
Number of Residues	1
Details	binding site for residue CL D 1406

Chain	Residue
D	ARG1149

---

site_id	AF3
Number of Residues	3
Details	binding site for residue CL D 1407

Chain	Residue
C	HOH1510
D	ALA1271
D	HOH1597

---

site_id	AF4
Number of Residues	4
Details	binding site for residue CL D 1408

Chain	Residue
D	HIS1176
D	HIS1177
D	ASN1178
D	HOH1560

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18436240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RF5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DVI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N3R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W6E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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