3P0V
| anti-EGFR/HER3 Fab DL11 alone | Descriptor: | CALCIUM ION, Fab DL11 heavy chain, Fab DL11 light chain | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2010-09-29 | Release date: | 2011-10-19 | Last modified: | 2012-03-21 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell, 20, 2011
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3GRW
| FGFR3 in complex with a Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... | Authors: | Wiesmann, C. | Deposit date: | 2009-03-26 | Release date: | 2009-05-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. J.Clin.Invest., 119, 2009
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5VSZ
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5VSX
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5NB9
| Structure of the N-terminal domain of the Escherichia Coli ProQ RNA binding protein | Descriptor: | RNA chaperone ProQ | Authors: | Gonzales, G, Hardwick, S, Maslen, S, Skehel, M, Holmqvist, E, Vogel, J, Bateman, A, Luisi, B, Broadhurst, R. | Deposit date: | 2017-03-01 | Release date: | 2017-05-03 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structure of the Escherichia coli ProQ RNA-binding protein. RNA, 23, 2017
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5NBB
| Structure of the C-terminal domain of the Escherichia Coli ProQ RNA binding protein | Descriptor: | RNA chaperone ProQ | Authors: | Gonzales, G, Hardwick, S, Maslen, S, Skehel, M, Holmqvist, E, Vogel, J, Bateman, A, Luisi, B, Broadhurst, R. | Deposit date: | 2017-03-01 | Release date: | 2017-05-03 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structure of the Escherichia coli ProQ RNA-binding protein. RNA, 23, 2017
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4GMQ
| Ribosome-binding domain of Zuo1 | Descriptor: | Putative ribosome associated protein | Authors: | Kopp, J, Bange, G, Sinning, I. | Deposit date: | 2012-08-16 | Release date: | 2012-12-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural characterization of a eukaryotic chaperone-the ribosome-associated complex. Nat.Struct.Mol.Biol., 20, 2013
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4GNI
| Structure of the Ssz1 ATPase bound to ATP and Magnesium | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein | Authors: | Bange, G, Sinning, I. | Deposit date: | 2012-08-17 | Release date: | 2012-12-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.796 Å) | Cite: | Structural characterization of a eukaryotic chaperone-the ribosome-associated complex. Nat.Struct.Mol.Biol., 20, 2013
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2MNX
| Major groove orientation of the (2S)-N6-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosine DNA adduct induced by 1,2-epoxy-3-butene | Descriptor: | 5'-D(*CP*GP*GP*AP*CP*(6HB)P*AP*GP*AP*AP*G)-3', 5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3' | Authors: | Kowal, E.A, Kotapati, S, Turo, M, Tretyakova, N, Stone, M.P. | Deposit date: | 2014-04-16 | Release date: | 2014-10-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Major Groove Orientation of the (2S)-N(6)-(2-Hydroxy-3-buten-1-yl)-2'-deoxyadenosine DNA Adduct Induced by 1,2-Epoxy-3-butene. Chem.Res.Toxicol., 27, 2014
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4ZCG
| Crystal Structure of human GGT1 in complex with Glutamate (with all atoms of glutamate) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTAMIC ACID, ... | Authors: | Terzyan, S, Hanigan, M. | Deposit date: | 2015-04-15 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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4ZBK
| Crystal Structure of human GGT1 in complex with GGsTop inhibitor | Descriptor: | (2S)-2-amino-4-[(S)-hydroxy(methoxy)phosphoryl]butanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Terzyan, S, Hanigan, M. | Deposit date: | 2015-04-14 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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4ZC6
| Crystal Structure of human GGT1 in complex with Serine Borate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Gamma-glutamyltranspeptidase 1 heavy chain, ... | Authors: | Terzyan, S, Hanigan, M. | Deposit date: | 2015-04-15 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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2R0K
| Protease domain of HGFA with inhibitor Fab58 | Descriptor: | Hepatocyte growth factor activator, antibody heavy chain of Fab58, Fab portion only, ... | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2007-08-20 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2R0L
| Short Form HGFA with Inhibitory Fab75 | Descriptor: | Hepatocyte growth factor activator, antibody heavy chain, Fab portion only, ... | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2007-08-20 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104, 2007
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5M6S
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6F62
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6F64
| Crystal structure of the SYCP1 C-terminal back-to-back assembly | Descriptor: | ACETATE ION, Synaptonemal complex protein 1 | Authors: | Dunce, J.M, Millan, C, Uson, I, Davies, O.R. | Deposit date: | 2017-12-04 | Release date: | 2018-06-06 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly. Nat. Struct. Mol. Biol., 25, 2018
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6F63
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3G6J
| C3b in complex with a C3b specific Fab | Descriptor: | CALCIUM ION, Complement C3 alpha chain, Complement C3 beta chain, ... | Authors: | Wiesmann, C. | Deposit date: | 2009-02-06 | Release date: | 2009-03-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement J.Biol.Chem., 284, 2009
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6F5X
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3L95
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4DKD
| Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-34, ... | Authors: | Ma, X, Bazan, J.F, Starovasnik, M.A. | Deposit date: | 2012-02-03 | Release date: | 2012-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
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4DKC
| Crystal Structure of Human Interleukin-34 | Descriptor: | Interleukin-34, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Ma, X, Bazan, J.F, Starovasnik, M.A. | Deposit date: | 2012-02-03 | Release date: | 2012-04-11 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
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7NZM
| Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Yan, Y, Hardwick, S, Ron, D. | Deposit date: | 2021-03-24 | Release date: | 2021-09-29 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
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4Z9O
| Crystal Structure of human GGT1 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Terzyan, S.S, Hanigan, M.H. | Deposit date: | 2015-04-10 | Release date: | 2015-06-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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