3V1G
| Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | Authors: | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | Deposit date: | 2011-12-09 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health To be Published
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3BXQ
| The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition | Descriptor: | ZINC ION, insulin A chain, insulin B chain | Authors: | Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A. | Deposit date: | 2008-01-14 | Release date: | 2008-05-20 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283, 2008
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1TGL
| A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTRE OF A TRIACYLGLYCEROL LIPASE | Descriptor: | TRIACYL-GLYCEROL ACYLHYDROLASE | Authors: | Brady, L, Brzozowski, A.M, Derewenda, Z.S, Dodson, E.J, Dodson, G.G, Tolley, S.P, Turkenburg, J.P, Christiansen, L, Huge-Jensen, B, Norskov, L, Thim, L. | Deposit date: | 1990-02-05 | Release date: | 1990-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Nature, 343, 1990
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3FQ9
| Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | Descriptor: | Insulin, ZINC ION | Authors: | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | Deposit date: | 2009-01-07 | Release date: | 2009-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J.Biol.Chem., 284, 2009
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2OLB
| OLIGOPEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH TRI-LYSINE | Descriptor: | ACETATE ION, OLIGO-PEPTIDE BINDING PROTEIN, TRIPEPTIDE LYS-LYS-LYS, ... | Authors: | Tame, J, Wilkinson, A.J. | Deposit date: | 1995-09-10 | Release date: | 1996-01-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands. Structure, 3, 1995
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6I3G
| Crystal structure of a putative peptide binding protein AppA from Clostridium difficile | Descriptor: | ABC transporter, substrate-binding protein, family 5, ... | Authors: | Hughes, A.M, Wilkinson, A, Dodson, E. | Deposit date: | 2018-11-06 | Release date: | 2019-04-10 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the putative peptide-binding protein AppA from Clostridium difficile. Acta Crystallogr.,Sect.F, 75, 2019
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1JET
| OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KAK | Descriptor: | OLIGO-PEPTIDE BINDING PROTEIN, PEPTIDE LYS ALA LYS, URANYL (VI) ION | Authors: | Tame, J, Wilkinson, A.J. | Deposit date: | 1996-07-03 | Release date: | 1997-05-15 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The role of water in sequence-independent ligand binding by an oligopeptide transporter protein. Nat.Struct.Biol., 3, 1996
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1OLC
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3EXX
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1RKM
| STRUCTURE OF OPPA | Descriptor: | OLIGO-PEPTIDE BINDING PROTEIN | Authors: | Sleigh, S.H, Tame, J.R.H, Wilkinson, A.J. | Deposit date: | 1997-03-25 | Release date: | 1997-07-29 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Peptide binding in OppA, the crystal structures of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lysyllysine. Biochemistry, 36, 1997
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1QKA
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1QKB
| OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KVK | Descriptor: | ACETATE ION, PEPTIDE LYS-VAL-LYS, PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN, ... | Authors: | Tame, J.R.H, Sleigh, S.H, Wilkinson, A.J. | Deposit date: | 1999-07-14 | Release date: | 1999-09-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic and Calorimetric Analysis of Peptide Binding to Oppa Protein J.Mol.Biol., 291, 1999
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1OLA
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2QIU
| Structure of Human Arg-Insulin | Descriptor: | Insulin, ZINC ION | Authors: | Sreekanth, R, Pattabhi, V, Rajan, S.S. | Deposit date: | 2007-07-05 | Release date: | 2008-02-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural interpretation of reduced insulin activity as seen in the crystal structure of human Arg-insulin Biochimie, 90, 2008
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6QP3
| Crystal structure of the PLP-bound C-S lyase from Bacillus subtilis (strain 168) | Descriptor: | ACETATE ION, Cystathionine beta-lyase PatB, PYRIDOXAL-5'-PHOSPHATE | Authors: | Herman, R, Rudden, M, Wilkinson, A.J, Hanai, S, Thomas, G.H. | Deposit date: | 2019-02-13 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The molecular basis of thioalcohol production in human body odour. Sci Rep, 10, 2020
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6QP1
| Crystal structure of the PLP-bound C-S lyase in the external aldimine form from Staphylococcus hominis complexed with an inhibitor, L-cycloserine. | Descriptor: | Aminotransferase, [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate | Authors: | Herman, R, Rudden, M, Wilkinson, A.J, Hanai, S, Thomas, G.H. | Deposit date: | 2019-02-13 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | The molecular basis of thioalcohol production in human body odour. Sci Rep, 10, 2020
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6QP2
| Crystal structure of the PLP-bound C-S lyase from Staphylococcus hominis | Descriptor: | Aminotransferase, PYRIDOXAL-5'-PHOSPHATE, Polyhistidine tag | Authors: | Herman, R, Rudden, M, Wilkinson, A.J, Hanai, S, Thomas, G.H. | Deposit date: | 2019-02-13 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The molecular basis of thioalcohol production in human body odour. Sci Rep, 10, 2020
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1TQF
| Crystal structure of human Beta secretase complexed with inhibitor | Descriptor: | 3-{2-[(5-AMINOPENTYL)AMINO]-2-OXOETHOXY}-5-({[1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)PHENYL PHENYLMETHANESULFONATE, Beta-secretase 1 | Authors: | Munshi, S, Chen, Z, Kuo, L. | Deposit date: | 2004-06-17 | Release date: | 2004-11-09 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases. J.Med.Chem., 47, 2004
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1G7A
| 1.2 A structure of T3R3 human insulin at 100 K | Descriptor: | ACETONE, CHLORIDE ION, GLYCEROL, ... | Authors: | Smith, G.D, Pangborn, W.A, Blessing, R.H. | Deposit date: | 2000-11-09 | Release date: | 2001-08-03 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced? Acta Crystallogr.,Sect.D, 57, 2001
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1G7B
| 1.3 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K | Descriptor: | ACETONE, CHLORIDE ION, GLYCEROL, ... | Authors: | Smith, G.D, Pangborn, W.A, Blessing, R.H. | Deposit date: | 2000-11-09 | Release date: | 2001-08-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced? Acta Crystallogr.,Sect.D, 57, 2001
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4AXV
| Biochemical and structural characterization of the MpaA amidase as part of a conserved scavenging pathway for peptidoglycan derived peptides in gamma-proteobacteria | Descriptor: | 1,2-ETHANEDIOL, MPAA, ZINC ION | Authors: | Maqbool, A, Herve, M, Mengin-Lecreulx, D, Dodson, E, Wilkinson, A.J, Thomas, G.H. | Deposit date: | 2012-06-14 | Release date: | 2012-09-26 | Last modified: | 2020-03-04 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Mpaa is a Murein-Tripeptide-Specific Zinc Carboxypeptidase that Functions as Part of a Catabolic Pathway for Peptidoglycan Derived Peptides in Gamma-Proteobacteria. Biochem.J., 448, 2012
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1B58
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1B4Z
| OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KDK | Descriptor: | ACETATE ION, PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN), PROTEIN (PEPTIDE LYS-ASP-LYS), ... | Authors: | Tame, J.R.H, Sleigh, S.H, Wilkinson, A.J. | Deposit date: | 1999-01-04 | Release date: | 1999-01-13 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystallographic and calorimetric analysis of peptide binding to OppA protein. J.Mol.Biol., 291, 1999
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1B3G
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1B40
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