8YTX
 
 | | Tubulin-RB3-TTL in complex with compound SI9 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[2,3-d]pyrimidin-4-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-26 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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8YUA
 | | Tubulin-RB3-TTL in complex with compound SI10 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[3,2-d]pyrimidin-4-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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8WC3
 | | Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex | | Descriptor: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WC4
 | | Cryo-EM structure of the ZH8651-bound mTAAR1-Gs complex | | Descriptor: | 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WC7
 | | Cryo-EM structure of the ZH8667-bound mTAAR1-Gs complex | | Descriptor: | 2-[4-(3-fluorophenyl)phenyl]ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WC9
 | | Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex | | Descriptor: | 2-(4-bromophenyl)ethanamine, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WC8
 | | Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex | | Descriptor: | 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WCA
 | | Cryo-EM structure of the PEA-bound hTAAR1-Gs complex | | Descriptor: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WC5
 | | Cryo-EM structure of the TMA-bound mTAAR1-Gs complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WCB
 | | Cryo-EM structure of the CHA-bound mTAAR1-Gq complex | | Descriptor: | CYCLOHEXYLAMMONIUM ION, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WCC
 | | Cryo-EM structure of the CHA-bound mTAAR1 complex | | Descriptor: | CYCLOHEXYLAMMONIUM ION, Trace amine-associated receptor 1 | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8WC6
 | | Cryo-EM structure of the PEA-bound mTAAR1-Gs complex | | Descriptor: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | Deposit date: | 2023-09-11 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
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8Z7X
 | | SLC19A3-Thiamine inward structure | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7R
 | | SLC19A3 apo structure | | Descriptor: | Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7T
 | | SLC19A3-Pyridoxine outward structure | | Descriptor: | 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z80
 | | SLC19A2-Pyridoxine inward structure | | Descriptor: | 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol, Thiamine transporter 1 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7S
 | | SLC19A3-thiamine outward structure | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7W
 | | SLC19A3-Metformin outward structure | | Descriptor: | Metformin, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7V
 | | Slc19A3-Amprolium outward structure | | Descriptor: | Amprolium, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7Y
 | | SLC19A3-Fedratinib inward structure | | Descriptor: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7U
 | | SLC19A3-Fedratinib outward structure | | Descriptor: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7Z
 | | SLC19A2-Thiamine inward structure | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Thiamine transporter 1 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8GTK
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8GTJ
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8GTN
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