8GTJ

Crystal structure of IpaH7.8-LRR and GSDMB isoform-4 complex

Summary for 8GTJ

• Entry DOI: 10.2210/pdb8gtj/pdb
• Descriptor: Isoform 4 of Gasdermin-B, Probable E3 ubiquitin-protein ligase ipaH7.8 (3 entities in total)
• Functional Keywords: complex, effector, pyroptosis, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 149938.14

Authors

Zhong, X.,Hou, Y.J.,Ding, J. (deposition date: 2022-09-08, release date: 2023-04-12, Last modification date: 2023-11-29)

• Primary citation: Zhong, X.,Zeng, H.,Zhou, Z.,Su, Y.,Cheng, H.,Hou, Y.,She, Y.,Feng, N.,Wang, J.,Shao, F.,Ding, J.; Structural mechanisms for regulation of GSDMB pore-forming activity.; Nature, 616:598-605, 2023; PubMed: 36991125; DOI: 10.1038/s41586-023-05872-5

Experimental method

X-RAY DIFFRACTION (2.7 Å)