8GTJ

Crystal structure of IpaH7.8-LRR and GSDMB isoform-4 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Isoform 4 of Gasdermin-B	polymer	414	47128.6	2	UniProt (Q8TAX9) Pfam (PF04598) Pfam (PF17708)	Homo sapiens (human)	Gasdermin-like protein
2	B, D (B, D)	Probable E3 ubiquitin-protein ligase ipaH7.8	polymer	241	27840.5	2	UniProt (P18014) Pfam (PF12468)	Shigella flexneri	Probable RING-type E3 ubiquitin transferase ipaH7.8
3	E, F, G, H (A, B, C, D)	water	water		18.0	152	Chemie (HOH)

Sequence modifications

A, C: 1 - 407 (UniProt: Q8TAX9)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Arg -1	-	expression tag
Pro 0	-	expression tag
-	Glu 234	deletion
-	Lys 235	deletion
-	Asp 236	deletion
-	Gly 237	deletion
-	Ala 238	deletion
-	Ser 239	deletion
-	Ser 240	deletion
-	Cys 241	deletion
-	Leu 242	deletion

B, D: 23 - 262 (UniProt: P18014)

PDB	External Database	Details
Met 22	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149938.1
All*	Total formula weight	149938.1

*Water molecules are not included.