5GSB
| Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 37-3 | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ... | Authors: | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | Deposit date: | 2016-08-15 | Release date: | 2017-07-12 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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7JUO
| CBP bromodomain complexed with YF2-23 | Descriptor: | CREB-binding protein, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide | Authors: | Ratia, K.M, Xiong, R, Principe, D, Li, Y, Huang, F, Rana, A, Thatcher, G. | Deposit date: | 2020-08-20 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
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5GSX
| Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 142-2 | Descriptor: | 10-mer peptide from Spike protein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | Authors: | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | Deposit date: | 2016-08-17 | Release date: | 2017-06-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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6PIB
| Structure of the Klebsiella pneumoniae LpxH-AZ1 complex | Descriptor: | 1-[5-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, MANGANESE (II) ION, TETRAETHYLENE GLYCOL, ... | Authors: | Cho, J, Zhou, P. | Deposit date: | 2019-06-26 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117, 2020
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6PJ3
| Crystal structure of the Klebsiella pneumoniae LpxH/JH-LPH-33 complex | Descriptor: | 1,2-ETHANEDIOL, 1-[5-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, MANGANESE (II) ION, ... | Authors: | Cho, J, Zhou, P. | Deposit date: | 2019-06-27 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117, 2020
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6PH9
| Crystal Structure of the Klebsiella pneumoniae LpxH-lipid X complex | Descriptor: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Cho, J, Zhou, P. | Deposit date: | 2019-06-25 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117, 2020
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7BWJ
| crystal structure of SARS-CoV-2 antibody with RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ... | Authors: | Wang, X, Ge, J. | Deposit date: | 2020-04-14 | Release date: | 2020-06-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 584, 2020
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6LR6
| The crystal structure of human cytoplasmic LRS | Descriptor: | 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ... | Authors: | Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D. | Deposit date: | 2020-01-15 | Release date: | 2020-03-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.009 Å) | Cite: | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res., 48, 2020
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8WGW
| Local refinement of RBD-ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Wei, X, Zhang, Z. | Deposit date: | 2023-09-22 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
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8WGV
| BA.2(S375) Spike (S6P)/hACE2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Wei, X, Zhang, Z. | Deposit date: | 2023-09-22 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
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8XZR
| Crystal structure of folE riboswitch with 8-NH2 Guanine | Descriptor: | 8-AMINOGUANINE, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8XZW
| Crystal structure of THF-II riboswitch with THF and soaked with Ir | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8X5B
| Cryo-EM structures of human XPR1 in closed states | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, PHOSPHATE ION, ... | Authors: | Jiang, D.H, Yan, R. | Deposit date: | 2023-11-16 | Release date: | 2024-07-03 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Human XPR1 structures reveal phosphate export mechanism. Nature, 2024
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8XZL
| Crystal structure of folE riboswitch with DHF | Descriptor: | DIHYDROFOLIC ACID, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8XZE
| Crystal structure of THF-II riboswitch with THF and soaked with Ir | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, IRIDIUM ION, MAGNESIUM ION, ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8XZM
| Crystal structure of folE riboswitch with DHN | Descriptor: | 2-AMINO-7,8-DIHYDRO-6-(1,2,3-TRIHYDROXYPROPYL)-4(1H)-PTERIDINONE, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8XZK
| Crystal structure of folE riboswitch | Descriptor: | RNA (53-MER) | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8XZO
| Crystal structure of folE riboswitch with Guanine | Descriptor: | GUANINE, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8XZQ
| Crystal structure of folE riboswitch with 8-N Guanine | Descriptor: | 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8X5E
| Cryo-EM structure of human XPR1 in open state | Descriptor: | PHOSPHATE ION, Solute carrier family 53 member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Jiang, D.H, Yan, R. | Deposit date: | 2023-11-17 | Release date: | 2024-07-03 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Human XPR1 structures reveal phosphate export mechanism. Nature, 2024
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8XZP
| Crystal structure of folE riboswitch with 8-CH3 Guanine | Descriptor: | 2-azanyl-8-methyl-1,9-dihydropurin-6-one, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8XZN
| Crystal structure of folE riboswitch with BH4 | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, MAGNESIUM ION, RNA (53-MER), ... | Authors: | Li, C.Y, Ren, A.M. | Deposit date: | 2024-01-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Res., 52, 2024
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8X5F
| human XPR1 in complex with InsP6 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Jiang, D.H, Yan, R. | Deposit date: | 2023-11-17 | Release date: | 2024-07-03 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Human XPR1 structures reveal phosphate export mechanism. Nature, 2024
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6UE5
| Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide | Descriptor: | 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... | Authors: | Knapp, M.S, Shu, W, Xie, L, Bussiere, D.E. | Deposit date: | 2019-09-20 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
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6KXW
| Crystal structure of human aquaporin AQP7 in bound to glycerol | Descriptor: | Aquaporin-7, GLYCEROL | Authors: | Zhang, L, Yao, D, Zhou, F, Zhang, Q, Zhou, L, Cao, Y. | Deposit date: | 2019-09-13 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | The structural basis for glycerol permeation by human AQP7 Sci Bull (Beijing), 66, 2020
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