6PH9

Crystal Structure of the Klebsiella pneumoniae LpxH-lipid X complex

Summary for 6PH9

Entry DOI	10.2210/pdb6ph9/pdb
Descriptor	UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, ... (7 entities in total)
Functional Keywords	lipid a, lpxh, lipid x, biosynthetic protein
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	31149.02
Authors	Cho, J.,Zhou, P. (deposition date: 2019-06-25, release date: 2020-02-12, Last modification date: 2023-10-11)
Primary citation	Cho, J.,Lee, M.,Cochrane, C.S.,Webster, C.G.,Fenton, B.A.,Zhao, J.,Hong, J.,Zhou, P. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc.Natl.Acad.Sci.USA, 117:4109-4116, 2020 Cited by PubMed: 32041866 DOI: 10.1073/pnas.1912876117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation