3ADE
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![BU of 3ade by Molmil](/molmil-images/mine/3ade) | Crystal Structure of Keap1 in Complex with Sequestosome-1/p62 | Descriptor: | Kelch-like ECH-associated protein 1, SULFATE ION, Sequestosome-1 | Authors: | Kurokawa, H, Yamamoto, M. | Deposit date: | 2010-01-19 | Release date: | 2010-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat.Cell Biol., 12, 2010
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7YFC
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![BU of 7yfc by Molmil](/molmil-images/mine/7yfc) | Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex | Descriptor: | CHOLESTEROL, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Im, D, Iwata, S, Asada, H. | Deposit date: | 2022-07-08 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
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7YFD
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![BU of 7yfd by Molmil](/molmil-images/mine/7yfd) | Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex | Descriptor: | 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, CHOLESTEROL, Engineered G-alpha-q, ... | Authors: | Im, D, Iwata, S, Asada, H. | Deposit date: | 2022-07-08 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
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3A6U
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![BU of 3a6u by Molmil](/molmil-images/mine/3a6u) | Crystal structure of MutT-8-OXO-dGMP-MN(II) complex | Descriptor: | 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Mutator mutT protein, ... | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2009-09-09 | Release date: | 2009-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base J.Biol.Chem., 285, 2010
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3A6S
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![BU of 3a6s by Molmil](/molmil-images/mine/3a6s) | Crystal structure of the MutT protein | Descriptor: | L(+)-TARTARIC ACID, Mutator mutT protein, SODIUM ION | Authors: | Nakamura, T, Yamagata, Y. | Deposit date: | 2009-09-09 | Release date: | 2009-10-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base J.Biol.Chem., 285, 2010
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7V5N
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![BU of 7v5n by Molmil](/molmil-images/mine/7v5n) | Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*GP*TP*TP*GP*GP*TP*GP*GP*TP*AP*GP*TP*TP*AP*CP*GP*TP*TP*CP*GP*C)-3'), IMIDAZOLE, ... | Authors: | Hishiki, A, Tong, J, Todoroki, K, Hashimoto, H. | Deposit date: | 2021-08-17 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection. Biosens.Bioelectron., 203, 2022
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2ZJU
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![BU of 2zju by Molmil](/molmil-images/mine/2zju) | Crystal Structure of Lymnaea stagnalis Acetylcholine Binding Protein (Ls-AChBP) Complexed with Imidacloprid | Descriptor: | (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, Acetylcholine-binding protein | Authors: | Okajima, T, Ihara, M, Yamashita, A, Oda, T, Morimoto, T, Matsuda, K. | Deposit date: | 2008-03-10 | Release date: | 2008-04-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin Invert.Neurosci., 8, 2008
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5ZUI
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![BU of 5zui by Molmil](/molmil-images/mine/5zui) | Crystal Structure of HSP104 from Chaetomium thermophilum | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Heat Shock Protein 104, SULFATE ION | Authors: | Hanazono, Y, Inoue, Y, Noguchi, K, Yohda, M, Shinohara, K, Takeda, K, Miki, K. | Deposit date: | 2018-05-07 | Release date: | 2019-06-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Split conformation of Chaetomium thermophilum Hsp104 disaggregase. Structure, 2021
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2D8B
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![BU of 2d8b by Molmil](/molmil-images/mine/2d8b) | Solution structure of the second tandem cofilin-domain of mouse twinfilin | Descriptor: | Twinfilin-1 | Authors: | Goroncy, A.K, Kigawa, T, Koshiba, S, Sato, M, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-02 | Release date: | 2006-06-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR solution structures of actin depolymerizing factor homology domains Protein Sci., 18, 2009
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2ZJV
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![BU of 2zjv by Molmil](/molmil-images/mine/2zjv) | Crystal Structure of Lymnaea stagnalis Acetylcholine Binding Protein (Ls-AChBP) Complexed with Clothianidin | Descriptor: | 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine, Acetylcholine-binding protein | Authors: | Okajima, T, Ihara, M, Yamashita, A, Oda, T, Morimoto, T, Matsuda, K. | Deposit date: | 2008-03-10 | Release date: | 2008-04-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin Invert.Neurosci., 8, 2008
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7F4X
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![BU of 7f4x by Molmil](/molmil-images/mine/7f4x) | Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... | Authors: | Yokoyama, T, Ostermann, A, Schrader, T.E. | Deposit date: | 2021-06-21 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION | Cite: | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
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3AL9
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![BU of 3al9 by Molmil](/molmil-images/mine/3al9) | Mouse Plexin A2 extracellular domain | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-A2 | Authors: | Nogi, T, Yasui, N, Mihara, E, Takagi, J. | Deposit date: | 2010-07-28 | Release date: | 2010-10-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for semaphorin signalling through the plexin receptor. Nature, 467, 2010
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3B21
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![BU of 3b21 by Molmil](/molmil-images/mine/3b21) | |
7Y1G
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![BU of 7y1g by Molmil](/molmil-images/mine/7y1g) | Crystal structure of human PRKACA complexed with DS01080522 | Descriptor: | 1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide, ZINC ION, cAMP-dependent protein kinase catalytic subunit alpha | Authors: | Suzuki, M, Ubukata, O, Toyoda, A. | Deposit date: | 2022-06-08 | Release date: | 2022-09-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model. Biochem.Biophys.Res.Commun., 621, 2022
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5Z5S
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![BU of 5z5s by Molmil](/molmil-images/mine/5z5s) | Crystal structure of the PPARgamma-LBD complexed with compound 13ab | Descriptor: | 3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... | Authors: | Matsui, Y, Hanzawa, H. | Deposit date: | 2018-01-19 | Release date: | 2018-10-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of DS-6930, a potent selective PPAR gamma modulator. Part I: Lead identification. Bioorg. Med. Chem., 26, 2018
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5ZJG
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![BU of 5zjg by Molmil](/molmil-images/mine/5zjg) | Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with Gly-Gly | Descriptor: | GLYCEROL, GLYCINE, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03 L-subunit, ... | Authors: | Hibi, T, Imaoka, M, Itoh, T, Wakayama, M. | Deposit date: | 2018-03-20 | Release date: | 2019-01-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Crystal structure analysis and enzymatic characterization of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens. Biosci. Biotechnol. Biochem., 83, 2019
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5Z6S
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![BU of 5z6s by Molmil](/molmil-images/mine/5z6s) | Crystal structure of the PPARgamma-LBD complexed with compound DS-6930 | Descriptor: | 3-[[6-(3,5-dimethylpyridin-2-yl)oxy-1-methyl-benzimidazol-2-yl]methoxy]benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... | Authors: | Matsui, Y, Hanzawa, H. | Deposit date: | 2018-01-25 | Release date: | 2018-10-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of DS-6930, a potent selective PPAR gamma modulator. Part II: Lead optimization. Bioorg. Med. Chem., 26, 2018
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7XZK
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3AFC
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![BU of 3afc by Molmil](/molmil-images/mine/3afc) | Mouse Semaphorin 6A extracellular domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Semaphorin-6A | Authors: | Yasui, N, Nogi, T, Mihara, E, Takagi, J. | Deposit date: | 2010-02-26 | Release date: | 2010-10-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for semaphorin signalling through the plexin receptor. Nature, 467, 2010
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3AL8
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![BU of 3al8 by Molmil](/molmil-images/mine/3al8) | Plexin A2 / Semaphorin 6A complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-A2, ... | Authors: | Nogi, T, Yasui, N, Mihara, E, Takagi, J. | Deposit date: | 2010-07-28 | Release date: | 2010-10-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for semaphorin signalling through the plexin receptor. Nature, 467, 2010
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5X1D
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![BU of 5x1d by Molmil](/molmil-images/mine/5x1d) | |
5X1A
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![BU of 5x1a by Molmil](/molmil-images/mine/5x1a) | |
5XPU
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![BU of 5xpu by Molmil](/molmil-images/mine/5xpu) | |
2PFK
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![BU of 2pfk by Molmil](/molmil-images/mine/2pfk) | |
5XPT
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![BU of 5xpt by Molmil](/molmil-images/mine/5xpt) | |