7Y1G
Crystal structure of human PRKACA complexed with DS01080522
Summary for 7Y1G
Entry DOI | 10.2210/pdb7y1g/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, 1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide, ZINC ION, ... (4 entities in total) |
Functional Keywords | serine/threonine protein kinase, protein kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 82625.22 |
Authors | Suzuki, M.,Ubukata, O.,Toyoda, A. (deposition date: 2022-06-08, release date: 2022-09-28, Last modification date: 2024-04-03) |
Primary citation | Toyota, A.,Goto, M.,Miyamoto, M.,Nagashima, Y.,Iwasaki, S.,Komatsu, T.,Momose, T.,Yoshida, K.,Tsukada, T.,Matsufuji, T.,Ohno, A.,Suzuki, M.,Ubukata, O.,Kaneta, Y. Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model. Biochem.Biophys.Res.Commun., 621:157-161, 2022 Cited by PubMed: 35839742DOI: 10.1016/j.bbrc.2022.07.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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