1I5P
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1JG0
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![BU of 1jg0 by Molmil](/molmil-images/mine/1jg0) | Crystal structure of Escherichia coli thymidylate synthase complexed with 2'-deoxyuridine-5'-monophosphate and N,O-didansyl-L-tyrosine | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N,O-DIDANSYL-L-TYROSINE, thymidylate synthase | Authors: | Fritz, T.A, Tondi, D, Finer-Moore, J.S, Costi, M.P, Stroud, R.M. | Deposit date: | 2001-06-22 | Release date: | 2002-02-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Chem.Biol., 8, 2001
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1KEZ
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![BU of 1kez by Molmil](/molmil-images/mine/1kez) | Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE) | Descriptor: | ERYTHRONOLIDE SYNTHASE | Authors: | Tsai, S.-C, Miercke, L.J.W, Krucinski, J, Gokhale, R, Chen, J.C.-H, Foster, P.G, Cane, D.E, Khosla, C, Stroud, R.M. | Deposit date: | 2001-11-19 | Release date: | 2002-01-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc.Natl.Acad.Sci.USA, 98, 2001
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1KZI
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![BU of 1kzi by Molmil](/molmil-images/mine/1kzi) | Crystal Structure of EcTS/dUMP/THF Complex | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (6S)-5,6,7,8-TETRAHYDROFOLATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... | Authors: | Fritz, T.A, Liu, L, Finer-Moore, J.S, Stroud, R.M. | Deposit date: | 2002-02-06 | Release date: | 2002-07-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry, 41, 2002
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1LCA
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![BU of 1lca by Molmil](/molmil-images/mine/1lca) | LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717 | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | Authors: | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | Deposit date: | 1995-06-22 | Release date: | 1995-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
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1KZJ
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![BU of 1kzj by Molmil](/molmil-images/mine/1kzj) | Crystal Structure of EcTS W80G/dUMP/CB3717 Complex | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | Authors: | Fritz, T.A, Liu, L, Finer-Moore, J.S, Stroud, R.M. | Deposit date: | 2002-02-06 | Release date: | 2002-07-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry, 41, 2002
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1KZK
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![BU of 1kzk by Molmil](/molmil-images/mine/1kzk) | JE-2147-HIV Protease Complex | Descriptor: | (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Reiling, K.K, Endres, N.F, Dauber, D.S, Craik, C.S, Stroud, R.M. | Deposit date: | 2002-02-06 | Release date: | 2002-04-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Anisotropic Dynamics of the JE-2147-HIV Protease Complex:
Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09 A Structure Biochemistry, 41, 2002
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1LCE
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![BU of 1lce by Molmil](/molmil-images/mine/1lce) | LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE | Authors: | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | Deposit date: | 1995-06-22 | Release date: | 1995-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
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1LCB
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1QZF
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![BU of 1qzf by Molmil](/molmil-images/mine/1qzf) | Crystal structure of DHFR-TS from Cryptosporidium hominis | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FOLIC ACID, ... | Authors: | O'Neil, R.H, Lilien, R.H, Donald, B.R, Stroud, R.M, Anderson, A.C. | Deposit date: | 2003-09-16 | Release date: | 2003-11-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase J.Biol.Chem., 278, 2003
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1R3E
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![BU of 1r3e by Molmil](/molmil-images/mine/1r3e) | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit | Descriptor: | 5'-R(*CP*UP*GP*UP*GP*UP*(FHU)P*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3', 5'-R(*CP*UP*GP*UP*GP*UP*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3', tRNA pseudouridine synthase B | Authors: | Pan, H, Agarwalla, S, Moustakas, D.T, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2003-10-01 | Release date: | 2003-11-04 | Last modified: | 2018-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit Proc.Natl.Acad.Sci.USA, 100, 2003
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1SQF
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![BU of 1sqf by Molmil](/molmil-images/mine/1sqf) | The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution | Descriptor: | S-ADENOSYLMETHIONINE, SUN protein | Authors: | Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M. | Deposit date: | 2004-03-18 | Release date: | 2004-05-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The First Structure of an RNA m5C Methyltransferase,
Fmu, Provides Insight into Catalytic Mechanism
and Specific Binding of RNA Substrate Structure, 11, 2003
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1R2J
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![BU of 1r2j by Molmil](/molmil-images/mine/1r2j) | FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, protein FkbI | Authors: | Watanabe, K, Khosla, C, Stroud, R.M, Tsai, S.-C. | Deposit date: | 2003-09-28 | Release date: | 2003-11-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis J.Mol.Biol., 334, 2003
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1R3F
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![BU of 1r3f by Molmil](/molmil-images/mine/1r3f) | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit | Descriptor: | tRNA pseudouridine synthase B | Authors: | Pan, H, Agarwalla, S, Moustakas, D.T, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2003-10-01 | Release date: | 2003-11-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit Proc.Natl.Acad.Sci.USA, 100, 2003
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1U7C
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![BU of 1u7c by Molmil](/molmil-images/mine/1u7c) | Crystal Structure of AmtB from E.Coli with Methyl Ammonium. | Descriptor: | METHYLAMINE, Probable ammonium transporter | Authors: | Khademi, S, O'Connell III, J, Remis, J, Robles-Colmenares, Y, Miercke, L.J.W, Stroud, R.M. | Deposit date: | 2004-08-03 | Release date: | 2004-09-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A Science, 305, 2004
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1RC2
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![BU of 1rc2 by Molmil](/molmil-images/mine/1rc2) | 2.5 Angstrom Resolution X-ray Structure of Aquaporin Z | Descriptor: | 2-O-octyl-beta-D-glucopyranose, Aquaporin Z | Authors: | Savage, D.F, Egea, P.F, Robles, Y.C, O'Connell III, J.D, Stroud, R.M. | Deposit date: | 2003-11-03 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z Plos Biol., 1, 2003
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1U77
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![BU of 1u77 by Molmil](/molmil-images/mine/1u77) | Crystal Structure of Ammonia Channel AmtB from E. Coli | Descriptor: | Probable ammonium transporter | Authors: | Khademi, S, O'Connell III, J, Remis, J, Robles-Colmenares, Y, Miercke, L.J.W, Stroud, R.M. | Deposit date: | 2004-08-02 | Release date: | 2004-09-21 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A Science, 305, 2004
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1U7G
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![BU of 1u7g by Molmil](/molmil-images/mine/1u7g) | Crystal Structure of Ammonia Channel AmtB from E. Coli | Descriptor: | AMMONIA, AMMONIUM ION, Probable ammonium transporter, ... | Authors: | Khademi, S, O'Connell III, J, Remis, J, Robles-Colmenares, Y, Miercke, L.J.W, Stroud, R.M. | Deposit date: | 2004-08-03 | Release date: | 2004-09-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A Science, 305, 2004
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1RJ9
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![BU of 1rj9 by Molmil](/molmil-images/mine/1rj9) | Structure of the heterodimer of the conserved GTPase domains of the Signal Recognition Particle (Ffh) and Its Receptor (FtsY) | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Signal Recognition Protein, ... | Authors: | Egea, P.F, Shan, S.O, Napetschnig, J, Savage, D.F, Walter, P, Stroud, R.M. | Deposit date: | 2003-11-18 | Release date: | 2004-01-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Substrate twinning activates the signal recognition particle and its receptor Nature, 427, 2004
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1TSL
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1TSM
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1TQY
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![BU of 1tqy by Molmil](/molmil-images/mine/1tqy) | The Actinorhodin Ketosynthase/Chain Length Factor | Descriptor: | ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ... | Authors: | Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M. | Deposit date: | 2004-06-18 | Release date: | 2004-07-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An antibiotic factory caught in action. Nat.Struct.Mol.Biol., 11, 2004
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1TJS
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![BU of 1tjs by Molmil](/molmil-images/mine/1tjs) | E. COLI THYMIDYLATE SYNTHASE | Descriptor: | PHOSPHATE ION, THYMIDYLATE SYNTHASE | Authors: | Stout, T.J, Sage, C.R, Stroud, R.M. | Deposit date: | 1997-06-27 | Release date: | 1998-07-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
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1TDU
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![BU of 1tdu by Molmil](/molmil-images/mine/1tdu) | E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE (DURD) | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE, PHOSPHATE ION, ... | Authors: | Stout, T.J, Sage, C.R, Stroud, R.M. | Deposit date: | 1997-06-25 | Release date: | 1998-07-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
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1SQG
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![BU of 1sqg by Molmil](/molmil-images/mine/1sqg) | The crystal structure of the E. coli Fmu apoenzyme at 1.65 A resolution | Descriptor: | SUN protein | Authors: | Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M. | Deposit date: | 2004-03-18 | Release date: | 2004-05-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The First Structure of an RNA m5C Methyltransferase,
Fmu, Provides Insight into Catalytic Mechanism
and Specific Binding of RNA Substrate Structure, 11, 2003
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