1KZK

JE-2147-HIV Protease Complex

Summary for 1KZK

• Entry DOI: 10.2210/pdb1kzk/pdb
• Related: 1hpx
• Related PRD ID: PRD_000566
• Descriptor: Protease, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: hiv protease complex, anisotropic displacement parameters, viral protein, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22666.85

Authors

Reiling, K.K.,Endres, N.F.,Dauber, D.S.,Craik, C.S.,Stroud, R.M. (deposition date: 2002-02-06, release date: 2002-04-03, Last modification date: 2023-08-16)

• Primary citation: Reiling, K.K.,Endres, N.F.,Dauber, D.S.,Craik, C.S.,Stroud, R.M.; Anisotropic Dynamics of the JE-2147-HIV Protease Complex: Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09 A Structure; Biochemistry, 41:4582-4594, 2002; PubMed: 11926820; DOI: 10.1021/bi011781z

Experimental method

X-RAY DIFFRACTION (1.09 Å)