1HPX

HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272

Summary for 1HPX

Entry DOI	10.2210/pdb1hpx/pdb
Related PRD ID	PRD_000562
Descriptor	HIV-1 PROTEASE, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide (3 entities in total)
Functional Keywords	acid protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22275.35
Authors	Bhat, T.N.,Erickson, J.W. (deposition date: 1995-05-18, release date: 1996-03-08, Last modification date: 2024-02-07)
Primary citation	Baldwin, E.T.,Bhat, T.N.,Gulnik, S.,Liu, B.,Topol, I.A.,Kiso, Y.,Mimoto, T.,Mitsuya, H.,Erickson, J.W. Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine. Structure, 3:581-590, 1995 Cited by PubMed: 8590019 DOI: 10.1016/S0969-2126(01)00192-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation