1QZF

Crystal structure of DHFR-TS from Cryptosporidium hominis

Summary for 1QZF

Entry DOI	10.2210/pdb1qzf/pdb
Descriptor	bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
Functional Keywords	bifunctional enzyme, oxidoreductase, transferase
Biological source	Cryptosporidium hominis
Total number of polymer chains	5
Total formula weight	311174.94
Authors	O'Neil, R.H.,Lilien, R.H.,Donald, B.R.,Stroud, R.M.,Anderson, A.C. (deposition date: 2003-09-16, release date: 2003-11-11, Last modification date: 2023-08-23)
Primary citation	O'Neil, R.H.,Lilien, R.H.,Donald, B.R.,Stroud, R.M.,Anderson, A.C. Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase J.Biol.Chem., 278:52980-52987, 2003 Cited by PubMed: 14555647 DOI: 10.1074/jbc.M310328200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation