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8ENE
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BU of 8ene by Molmil
Aldehyde dehydrogenase 1 family member A1 from human liver
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retinal dehydrogenase 1
Authors:Zhang, Z.
Deposit date:2022-09-29
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
8EKW
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BU of 8ekw by Molmil
Cryo-EM structure of human PRDX4
Descriptor: Peroxiredoxin-4
Authors:Su, C.C.
Deposit date:2022-09-22
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
8EOR
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BU of 8eor by Molmil
Liver carboxylesterase 1
Descriptor: ETHYL ACETATE, Liver carboxylesterase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhang, Z, Yu, E.
Deposit date:2022-10-04
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
8EM2
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BU of 8em2 by Molmil
Cryo-EM structure of the human GDH/6PGL endoplasmic bifunctional protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GDH/6PGL endoplasmic bifunctional protein
Authors:Su, C.C.
Deposit date:2022-09-26
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
8FEX
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BU of 8fex by Molmil
Inactivate state of Maribacter polysiphoniae Argonuate (short pAgo system)
Descriptor: TIR-APAZ, short pAgo
Authors:Shen, Z.F, Yang, X.Y, Fu, T.M.
Deposit date:2022-12-06
Release date:2023-08-23
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
7XNR
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BU of 7xnr by Molmil
SARS-CoV-2 Omicron BA.2.13 variant spike
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Wang, X, Wang, L.
Deposit date:2022-04-29
Release date:2022-07-13
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection.
Nature, 608, 2022
7X6A
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BU of 7x6a by Molmil
SARS-CoV-2 BA.2 variant spike protein in complex with Fab BD55-5840
Descriptor: Heavy chain of Fab BD55-5840, Light chain of Fab BD55-5840, Spike glycoprotein
Authors:Wang, X, Wang, L.
Deposit date:2022-03-07
Release date:2022-07-13
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection.
Nature, 608, 2022
5KU3
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BU of 5ku3 by Molmil
BRD4 bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone)
Descriptor: 1,2-ETHANEDIOL, 1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone, Bromodomain-containing protein 4, ...
Authors:Murray, J.M, Huang, W.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
7D4B
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BU of 7d4b by Molmil
Crystal structure of 4-1BB in complex with a VHH
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Wang, C.
Deposit date:2020-09-23
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
7CZD
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BU of 7czd by Molmil
Crystal structure of PD-L1 in complex with a VHH
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ...
Authors:Wang, C.
Deposit date:2020-09-08
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
1PZV
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BU of 1pzv by Molmil
Crystal structures of two UBC (E2) enzymes of the ubiquitin-conjugating system in Caenorhabditis elegans
Descriptor: Probable ubiquitin-conjugating enzyme E2-19 kDa
Authors:Schormann, N, Lin, G, Li, S, Symersky, J, Qiu, S, Finley, J, Luo, D, Stanton, A, Carson, M, Luo, M, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2003-07-14
Release date:2003-07-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structures of two UBC (E2) enzymes of the ubiquitin-conjugating system in Caenorhabditis elegans
To be Published
8SNB
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BU of 8snb by Molmil
atomic model of sea urchin sperm doublet microtubule (48-nm periodicity)
Descriptor: ATP6V1FNB, C20Orf85, C4orf45, ...
Authors:Zeng, J, Zhang, R.
Deposit date:2023-04-26
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural specializations of the sperm tail.
Cell, 2023
8T1H
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BU of 8t1h by Molmil
Cryo-EM structure of a full-length, native Drp1 dimer
Descriptor: Dynamin-1-like protein
Authors:Rochon, K, Mears, J.A.
Deposit date:2023-06-02
Release date:2024-02-21
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (5.97 Å)
Cite:Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1.
Nat Commun, 15, 2024
7SCG
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BU of 7scg by Molmil
FH210 bound Mu Opioid Receptor-Gi Protein Complex
Descriptor: (2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, H, Kobilka, B.
Deposit date:2021-09-28
Release date:2022-04-20
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists.
Angew.Chem.Int.Ed.Engl., 61, 2022
7T6B
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BU of 7t6b by Molmil
Structure of S1PR2-heterotrimeric G13 signaling complex
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, X, Chen, H.
Deposit date:2021-12-13
Release date:2022-04-06
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structure of S1PR2-heterotrimeric G 13 signaling complex.
Sci Adv, 8, 2022
8SP3
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BU of 8sp3 by Molmil
Asymmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid
Descriptor: MAGNESIUM ION, TIR-APAZ, guide RNA, ...
Authors:Shen, Z.F, Yang, X.Y, Fu, T.M.
Deposit date:2023-05-01
Release date:2023-08-23
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
8SPO
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BU of 8spo by Molmil
Tetramerized activation of MapSPARTA bound with NAD+
Descriptor: MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Piwi domain-containing protein, ...
Authors:Shen, Z.F, Yang, X.Y, Fu, T.M.
Deposit date:2023-05-03
Release date:2023-08-23
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
8SP0
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BU of 8sp0 by Molmil
Symmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid
Descriptor: MAGNESIUM ION, TIR-APAZ, guide RNA, ...
Authors:Shen, Z.F, Yang, X.Y, Fu, T.M.
Deposit date:2023-05-01
Release date:2023-08-23
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
8SQU
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BU of 8squ by Molmil
Monomeric MapSPARTA bound with guide RNA and target DNA hybrid
Descriptor: MAGNESIUM ION, TIR-APAZ, guide RNA, ...
Authors:Shen, Z.F, Yang, X.Y, Fu, T.M.
Deposit date:2023-05-04
Release date:2023-08-23
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
5ETX
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BU of 5etx by Molmil
Crystal structure of HCV NS3/4A protease A156T variant in complex with 5172-Linear (MK-5172 linear analogue)
Descriptor: CHLORIDE ION, NS3 protease, ZINC ION, ...
Authors:Soumana, D, Yilmaz, N.K, Ali, A, Prachanronarong, K.L, Aydin, C, Schiffer, C.A.
Deposit date:2015-11-18
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172.
Acs Chem.Biol., 11, 2016
3KXO
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BU of 3kxo by Molmil
An orally active inhibitor bound at the active site of HPGDS
Descriptor: 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide, GLUTATHIONE, Glutathione-requiring prostaglandin D synthase, ...
Authors:Kiefer, J.R, Day, J.E, Thorarensen, A.
Deposit date:2009-12-03
Release date:2010-09-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase
TO BE PUBLISHED
3M0C
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BU of 3m0c by Molmil
The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
Descriptor: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
Authors:Spraggon, G, Hampton, E.N.
Deposit date:2010-03-02
Release date:2011-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (7.01 Å)
Cite:The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
To be Published
5VP9
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BU of 5vp9 by Molmil
Crystal structure of HCV NS3/4A protease in complex with AM-07, an analogue of 5172-mcP1P3
Descriptor: NS4A cofactor -- NS3 protein chimera, SULFATE ION, ZINC ION, ...
Authors:Matthew, A.N, Schiffer, C.A.
Deposit date:2017-05-04
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
J. Med. Chem., 60, 2017
5WVE
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BU of 5wve by Molmil
Apaf-1-Caspase-9 holoenzyme
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Caspase, ...
Authors:Li, Y, Zhou, M, Hu, Q, Shi, Y.
Deposit date:2016-12-24
Release date:2017-02-08
Last modified:2017-03-01
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VOJ
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BU of 5voj by Molmil
Crystal structure of HCV NS3/4A protease in complex with JZ01-15, an analogue of 5172-mcP1P3
Descriptor: NS4A cofactor -- NS3 protein chimera, SULFATE ION, ZINC ION, ...
Authors:Matthew, A.N, Schiffer, C.A.
Deposit date:2017-05-03
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
J. Med. Chem., 60, 2017

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数据于2024-06-26公开中

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