3M0C

The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor

Summary for 3M0C

• Entry DOI: 10.2210/pdb3m0c/pdb
• Related: 1IJQ 1N7D 2QTW 3GCX
• Descriptor: Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: protein complex, beta propeller, cholesterol clearance, pcsk9, ldlr, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, ldl, lipid transport, membrane, receptor, transmembrane, transport, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q8NBP7 Q8NBP7; Cell membrane; Single-pass type I membrane protein: P01130
• Total number of polymer chains: 3
• Total formula weight: 160154.66

Authors

Spraggon, G.,Hampton, E.N. (deposition date: 2010-03-02, release date: 2011-03-16, Last modification date: 2023-09-06)

• Primary citation: Li, J.,Gavigan, J.A.,Zheng, G.,Huang, W.,Yowe, D.,Geisse, S.,Harris, J.L.,Lesley, S.A.,Spraggon, G.; The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor; To be Published,

Experimental method

X-RAY DIFFRACTION (7.01 Å)