3M0C
The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Proprotein convertase subtilisin/kexin type 9 | polymer | 124 | 14019.7 | 1 | UniProt (Q8NBP7) Pfam (PF05922) In PDB | Homo sapiens (human) | Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1 |
2 | B | Proprotein convertase subtilisin/kexin type 9 | polymer | 546 | 58320.7 | 1 | UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) In PDB | Homo sapiens (human) | Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1 |
3 | C | Low-density lipoprotein receptor | polymer | 791 | 87694.0 | 1 | UniProt (P01130) Pfam (PF00057) Pfam (PF00058) Pfam (PF14670) In PDB | Homo sapiens (human) | LDL receptor |
4 | C | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) |
Sequence modifications
B: 153 - 692 (UniProt: Q8NBP7)
C: -17 - 767 (UniProt: P01130)
PDB | External Database | Details |
---|---|---|
Tyr 374 | Asp 374 | engineered mutation |
His 693 | - | expression tag |
His 694 | - | expression tag |
His 695 | - | expression tag |
His 696 | - | expression tag |
His 697 | - | expression tag |
His 698 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 768 | - | expression tag |
His 769 | - | expression tag |
His 770 | - | expression tag |
His 771 | - | expression tag |
His 772 | - | expression tag |
His 773 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 160034.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 120.2 | |
All* | Total formula weight | 160154.7 |