3M0C

The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Proprotein convertase subtilisin/kexin type 9	polymer	124	14019.7	1	UniProt (Q8NBP7) Pfam (PF05922)	Homo sapiens (human)	Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1
2	B (B)	Proprotein convertase subtilisin/kexin type 9	polymer	546	58320.7	1	UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463)	Homo sapiens (human)	Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1
3	C (C)	Low-density lipoprotein receptor	polymer	791	87694.0	1	UniProt (P01130) Pfam (PF00057) Pfam (PF00058) Pfam (PF14670)	Homo sapiens (human)	LDL receptor
4	D, E, F (C)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)

Sequence modifications

B: 153 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
Tyr 374	Asp 374	engineered mutation
His 693	-	expression tag
His 694	-	expression tag
His 695	-	expression tag
His 696	-	expression tag
His 697	-	expression tag
His 698	-	expression tag

C: -17 - 767 (UniProt: P01130)

PDB	External Database	Details
His 768	-	expression tag
His 769	-	expression tag
His 770	-	expression tag
His 771	-	expression tag
His 772	-	expression tag
His 773	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	160034.4
Non-Polymers*	Number of molecules	3
	Total formula weight	120.2
All*	Total formula weight	160154.7

*Water molecules are not included.