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Structure of NS2B-NS3 Protease from Zika Virus caught after self-cleavage
Descriptor:	CHLORIDE ION, Serine protease NS3, Serine protease subunit NS2B
Authors:	Phoo, W.W, Li, Y.
Deposit date:	2016-06-27
Release date:	2016-10-26
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (1.839 Å)
Cite:	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage. Nat Commun, 7, 2016

5YVJ

Crystal structure of full length NS2B47-NS3 (gD4NS2BNS3) from Dengue virus 4 in open conformation
Descriptor:	GLYCEROL, Genome polyprotein
Authors:	Phoo, W.W, El Sahili, A.
Deposit date:	2017-11-26
Release date:	2018-11-28
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.508 Å)
Cite:	Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain To Be Published

5YVV

Crystal structure of full length NS3 protein (gD4NS2BNS3) from DENV4 in closed conformation
Descriptor:	Genome polyprotein
Authors:	PHOO, W.W, Sahili, A.E.
Deposit date:	2017-11-27
Release date:	2018-12-05
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (3.097 Å)
Cite:	Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain To Be Published

5YVW

Crystal structure of full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation
Descriptor:	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Genome polyprotein
Authors:	PHOO, W.W, El Sahili, A.
Deposit date:	2017-11-27
Release date:	2018-12-05
Last modified:	2024-03-27
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain To Be Published

5YW1

Crystal structure of full length NS3 protein (eD4NS2BNS3) in complex with Bovine Pancreatic Trypsin Inhibitor
Descriptor:	FLAVIVIRUS_NS2B, PTI protein, Peptidase S7
Authors:	Phoo, W.W, El Sahili, A.
Deposit date:	2017-11-28
Release date:	2019-01-02
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain To Be Published

5YVU

Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
Descriptor:	GLYCEROL, Genome polyprotein, Pancreatic trypsin inhibitor
Authors:	Phoo, W.W, El Sahili, A.
Deposit date:	2017-11-27
Release date:	2018-11-28
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.491 Å)
Cite:	Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain To Be Published

5YVY

Crystal structure of unlinked full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation
Descriptor:	Genome polyprotein
Authors:	PHOO, W.W, El Sahili, A.
Deposit date:	2017-11-27
Release date:	2018-11-28
Last modified:	2024-03-27
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain To Be Published

5ZOB

Crystal structure of Zika NS3 protease with 4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide
Descriptor:	4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide, NS3 protease, Serine protease subunit NS2B
Authors:	Phoo, W.W, Wirawan, M.
Deposit date:	2018-04-12
Release date:	2018-10-17
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors. Antiviral Res., 160, 2018

5ZMQ

Crystal structure of Zika NS3 protease with phenylacetyl-Lys-Lys-Arg-COOH inhibitor
Descriptor:	Serine protease NS3, Serine protease subunit NS2B, peptide PAC-DLY-DLY-DAR
Authors:	Phoo, W.W, Wirawan, M.
Deposit date:	2018-04-05
Release date:	2018-10-17
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.987 Å)
Cite:	Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors. Antiviral Res., 160, 2018

5ZMS

Crystal structure of Zika NS3 protease in complex with 4-guanidinomethyl-phenylacetyl-Lys-Lys-Arg-H
Descriptor:	4-guanidinomethyl-phenylacetyl-Lys-Lys-Arg-H, NS3 protease, Serine protease subunit NS2B
Authors:	Phoo, W.W, Wirawan, M.
Deposit date:	2018-04-05
Release date:	2018-10-17
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors. Antiviral Res., 160, 2018

5GPI

Crystal Structures of Unlinked NS2B-NS3 Protease from Zika Virus and Its Complex with a Reverse Peptide Inhibitor
Descriptor:	NS2B cofactor, NS3 protease
Authors:	Phoo, W.W, Zhang, Z.Z.
Deposit date:	2016-08-02
Release date:	2016-12-14
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (1.578 Å)
Cite:	Crystal structure of unlinked NS2B-NS3 protease from Zika virus Science, 354, 2016

5YOF

Crystal structure of zika virus NS3 protease in complex with a dipeptide inhibitor
Descriptor:	(S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide, NS2B cofactor, NS3 Protease
Authors:	Phoo, W.W, Zhang, Z.Z.
Deposit date:	2017-10-27
Release date:	2018-03-21
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.51 Å)
Cite:	Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor Structure, 26, 2018

5YOD

Crystal structure of zika virus NS3 protease in complex with a small molecule inhibitor
Descriptor:	BENZOIC ACID, NS2B cofactor, NS3 protease
Authors:	Phoo, W.W, Zhang, Z.Z.
Deposit date:	2017-10-27
Release date:	2018-03-21
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor Structure, 26, 2018

4V0R

DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH
Descriptor:	FORMIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:	Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D.
Deposit date:	2014-09-18
Release date:	2015-01-28
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. Plos Pathog., 11, 2015

5XC6

Dengue Virus 4 NS3 Helicase in complex with SSRNA SLA12
Descriptor:	NS3 Helicase, PHOSPHATE ION, RNA (5'-R(APGPUPUPGPUPUPAPGPUPCPU)-3')
Authors:	Swarbrick, C.M.D, Basavannacharya, C, Chan, K.W.K, Chan, S.A, Singh, D, Wei, N, Phoo, W.W, Luo, D, Lescar, J, Vasudevan, S.G.
Deposit date:	2017-03-22
Release date:	2017-11-08
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication Nucleic Acids Res., 45, 2017

5XC7

Dengue Virus 4 NS3 Helicase D290A mutant
Descriptor:	CHLORIDE ION, GLYCEROL, NS3 Helicase
Authors:	Swarbrick, C.M.D, Basavannacharya, C, Chan, K.W.K, Chan, S.A, Singh, D, Wei, N, Phoo, W.W, Luo, D, Lescar, J, Vasudevan, S.G.
Deposit date:	2017-03-22
Release date:	2017-11-08
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication Nucleic Acids Res., 45, 2017

4V0Q

Dengue Virus Full Length NS5 Complexed with SAH
Descriptor:	ACETATE ION, GLYCEROL, NS5 POLYMERASE, ...
Authors:	Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D.
Deposit date:	2014-09-18
Release date:	2015-01-28
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. Plos Pathog., 11, 2015

7VMV

Crystal structure of Dengue NS2B-NS3 Protease after secondary cleavage
Descriptor:	Core protein
Authors:	Quek, J.P.
Deposit date:	2021-10-09
Release date:	2022-07-06
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (3.351 Å)
Cite:	Dynamic Interactions of Post Cleaved NS2B Cofactor and NS3 Protease Identified by Integrative Structural Approaches. Viruses, 14, 2022

5H4I

Unlinked NS2B-NS3 Protease from Zika Virus in complex with a compound fragment
Descriptor:	ACETATE ION, NS2B cofactor, NS3 protease, ...
Authors:	Zhang, Z.Z, Li, Y.
Deposit date:	2016-10-31
Release date:	2016-12-14
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.004 Å)
Cite:	Crystal structure of unlinked NS2B-NS3 protease from Zika virus Science, 354, 2016

5H6V

Structure of Zika virus protease in complex with a dipeptide inhibitor
Descriptor:	(S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide, Genome polyprotein
Authors:	Zhang, Z, Chen, M.
Deposit date:	2016-11-15
Release date:	2017-06-14
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.422 Å)
Cite:	Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors Structure, 25, 2017

8WO0

CryoEM structure of ZIKV rsNS1 filament
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Non-structural protein 1
Authors:	Chew, B.L.A, Luo, D.
Deposit date:	2023-10-06
Release date:	2024-05-08
Method:	ELECTRON MICROSCOPY (8 Å)
Cite:	Structural basis of Zika virus NS1 multimerization and human antibody recognition Npj Viruses, 2, 2024

8WNU

ZIKV rsNS1 in complex with Fab GB5 and anti-fab nanobody
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-fab nanobody, Non-structural protein 1, ...
Authors:	Chew, B.L.A, Luo, D.
Deposit date:	2023-10-06
Release date:	2024-05-08
Last modified:	2024-11-06
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Structural basis of Zika virus NS1 multimerization and human antibody recognition Npj Viruses, 2, 2024

8WN8

CryoEM structure of ZIKV rsNS1
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Non-structural protein 1
Authors:	Chew, B.L.A, Luo, D.
Deposit date:	2023-10-05
Release date:	2024-05-08
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	Structural basis of Zika virus NS1 multimerization and human antibody recognition Npj Viruses, 2, 2024

8WO4

ZIKV rsNS1 in complex with Fab EB9 and anti-fab nanobody
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-fab nanobody, Non-structural protein 1, ...
Authors:	Chew, B.L.A, Luo, D.
Deposit date:	2023-10-06
Release date:	2024-05-08
Last modified:	2024-10-09
Method:	ELECTRON MICROSCOPY (2.8 Å)
Cite:	Structural basis of Zika virus NS1 multimerization and human antibody recognition Npj Viruses, 2, 2024

8WNP

ZIKV rsNS1 in complex with Fab AA12 and anti-fab nanobody
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-fab nanobody, Non-structural protein 1, ...
Authors:	Chew, B.L.A, Luo, D.
Deposit date:	2023-10-06
Release date:	2024-05-08
Last modified:	2024-10-30
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Structural basis of Zika virus NS1 multimerization and human antibody recognition Npj Viruses, 2, 2024

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Displayed results:	25
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