5XC6

Dengue Virus 4 NS3 Helicase in complex with SSRNA SLA12

Summary for 5XC6

• Entry DOI: 10.2210/pdb5xc6/pdb
• Related: 5XC7
• Descriptor: NS3 Helicase, RNA (5'-R(*AP*GP*UP*UP*GP*UP*UP*AP*GP*UP*CP*U)-3'), PHOSPHATE ION (3 entities in total)
• Functional Keywords: helicase, dengue ns3, rna, hydrolase, hydrolase-rna complex, hydrolase/rna
• Biological source: Dengue virus 4; More
• Cellular location: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side . Host nucleus . Secreted . Virion membrane ; Multi-pass membrane protein : M9P7S0
• Total number of polymer chains: 4
• Total formula weight: 110503.49

Authors

Swarbrick, C.M.D.,Basavannacharya, C.,Chan, K.W.K.,Chan, S.A.,Singh, D.,Wei, N.,Phoo, W.W.,Luo, D.,Lescar, J.,Vasudevan, S.G. (deposition date: 2017-03-22, release date: 2017-11-08, Last modification date: 2023-11-22)

• Primary citation: Swarbrick, C.M.D.,Basavannacharya, C.,Chan, K.W.K.,Chan, S.A.,Singh, D.,Wei, N.,Phoo, W.W.,Luo, D.,Lescar, J.,Vasudevan, S.G.; NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication; Nucleic Acids Res., 45:12904-12920, 2017; PubMed: 29165589; DOI: 10.1093/nar/gkx1127

Experimental method

X-RAY DIFFRACTION (2.9 Å)