7SMP
 
 | | CryoEM structure of NKCC1 Bu-I | | Descriptor: | 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, POTASSIUM ION, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2021-10-26 | | Release date: | 2022-09-28 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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8STE
 | | Cryo-EM structure of NKCC1 Fu_CTD | | Descriptor: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2023-05-10 | | Release date: | 2023-05-17 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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7SFL
 | | Human NKCC1 state Fu-II | | Descriptor: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2021-10-04 | | Release date: | 2022-09-28 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.87 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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6P2U
 | | Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate | | Descriptor: | 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Moseng, M.A, Page, R.C. | | Deposit date: | 2019-05-22 | | Release date: | 2019-06-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.
Febs Lett., 593, 2019
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6PMT
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7MXO
 | | CryoEM structure of human NKCC1 | | Descriptor: | CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2021-05-19 | | Release date: | 2022-09-28 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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7N3N
 | | CryoEM structure of human NKCC1 state Fu-I | | Descriptor: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2021-06-01 | | Release date: | 2022-09-28 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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7KF8
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7KF5
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7KF6
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7KF7
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6NHK
 | | Mortalin nucleotide binding domain in the ADP-bound state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Page, R.C, Moseng, M.A, Nix, J.C. | | Deposit date: | 2018-12-23 | | Release date: | 2019-04-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.777 Å) | | Cite: | Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
J.Phys.Chem.B, 123, 2019
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6VKS
 | | Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin | | Descriptor: | (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE | | Authors: | Moseng, M.A, Lyu, M. | | Deposit date: | 2020-01-22 | | Release date: | 2020-07-01 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.
Mbio, 11, 2020
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6VKT
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4KBO
 | | Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form | | Descriptor: | SODIUM ION, Stress-70 protein, mitochondrial | | Authors: | Amick, J, Page, R.C, Nix, J.C, Misra, S. | | Deposit date: | 2013-04-23 | | Release date: | 2014-04-02 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.
Protein Sci., 23, 2014
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