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8BCR
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BU of 8bcr by Molmil
DENV3 Methyltransferase in complexed with AT-9010 and SAH
Descriptor: Genome polyprotein, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Gauffre, P, Fattorini, V, Canard, B, Ferron, F.
Deposit date:2022-10-17
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.
Antiviral Res., 212, 2023
8PWK
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BU of 8pwk by Molmil
human HINT1 in complex with compound AT8003
Descriptor: Histidine triad nucleotide-binding protein 1, SODIUM ION, [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate
Authors:Zimberger, C, Canard, B, Ferron, F.
Deposit date:2023-07-20
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
1OKS
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BU of 1oks by Molmil
Crystal structure of the measles virus phosphoprotein XD domain
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, RNA POLYMERASE ALPHA SUBUNIT
Authors:Johansson, K, Bourhis, J.-M, Campanacci, V, Cambillau, C, Canard, B, Longhi, S.
Deposit date:2003-07-29
Release date:2003-09-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Measles Virus Phosphoprotein Domain Responsible for the Induced Folding of the C-Terminal Domain of the Nucleoprotein
J.Biol.Chem., 278, 2003
8CB3
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BU of 8cb3 by Molmil
SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Papain-like protease nsp3
Authors:Morin, B, Ferron, F, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2023-01-25
Release date:2024-02-07
Method:X-RAY DIFFRACTION (1.572 Å)
Cite:SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid
To Be Published
1R6A
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BU of 1r6a by Molmil
Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Descriptor: Genome polyprotein, RIBAVIRIN MONOPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Benarroch, D, Egloff, M.P, Mulard, L, Romette, J.L, Canard, B.
Deposit date:2003-10-15
Release date:2004-09-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.
J.Biol.Chem., 279, 2004
8C0G
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BU of 8c0g by Molmil
SARS-CoV nsp16-nsp10 complexed with N7-GTP
Descriptor: DI(HYDROXYETHYL)ETHER, Non-structural protein 7, SODIUM ION, ...
Authors:Ferron, F, Debarnot, C, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2022-12-16
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Observation of N7-GTP in nsp16-nsp10 Sars-CoV
To Be Published
6YU8
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BU of 6yu8 by Molmil
RNA Methyltransferase of Sudan Ebola Virus
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Ferron, F, Valle, C, Zamboni, V, Canard, B, Decroly, E.
Deposit date:2020-04-25
Release date:2021-02-17
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:First insights into the structural features of Ebola virus methyltransferase activities.
Nucleic Acids Res., 49, 2021
8PTS
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BU of 8pts by Molmil
human GUK1 in complex with compound AT8001
Descriptor: GLYCEROL, Guanylate kinase, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate
Authors:Zimberger, C, Canard, B, Ferron, F.
Deposit date:2023-07-14
Release date:2024-07-24
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
8PIE
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BU of 8pie by Molmil
Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010
Descriptor: GLYCEROL, Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate
Authors:Feracci, M, Chazot, A, Ferron, F, Alvarez, K, Canard, B.
Deposit date:2023-06-21
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
8QCH
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BU of 8qch by Molmil
Human Adenosine deaminase-like protein in complex with compound AT8001
Descriptor: Adenosine deaminase-like protein, DI(HYDROXYETHYL)ETHER, SODIUM ION, ...
Authors:Zimberger, C, canard, B, Ferron, F.
Deposit date:2023-08-26
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.442 Å)
Cite:The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
1QZ8
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BU of 1qz8 by Molmil
Crystal structure of SARS coronavirus NSP9
Descriptor: SULFATE ION, polyprotein 1ab
Authors:Egloff, M.P, Ferron, F, Campanacci, V, Longhi, S, Rancurel, C, Dutartre, H, Snijder, E.J, Gorbalenya, A.E, Cambillau, C, Canard, B.
Deposit date:2003-09-16
Release date:2004-02-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.
Proc.Natl.Acad.Sci.USA, 101, 2004
6G13
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BU of 6g13 by Molmil
C-terminal domain of MERS-CoV nucleocapsid
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein, ...
Authors:Nguyen, T.H.V, Ferron, F.P, Lichiere, J, Canard, B, Papageorgiou, N, Coutard, B.
Deposit date:2018-03-20
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein.
Acta Crystallogr D Struct Biol, 75, 2019
2CKW
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BU of 2ckw by Molmil
The 2.3 A resolution structure of the Sapporo virus RNA dependant RNA polymerase.
Descriptor: RNA-DIRECTED RNA POLYMERASE
Authors:Fullerton, S.W.B, Tucker, P.A, Rohayem, J, Coutard, B, Gebhardt, J, Gorbalenya, A, Canard, B.
Deposit date:2006-04-24
Release date:2006-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase.
J.Virol., 81, 2007
7ED5
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BU of 7ed5 by Molmil
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B.
Deposit date:2021-03-15
Release date:2022-02-16
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Nat Commun, 13, 2022
7OA4
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BU of 7oa4 by Molmil
Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001
Descriptor: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, FORMIC ACID, MANGANESE (II) ION, ...
Authors:Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K.
Deposit date:2021-04-19
Release date:2022-08-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options.
Iucrj, 11, 2024
5T2T
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BU of 5t2t by Molmil
Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001
Descriptor: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F.
Deposit date:2016-08-24
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.967 Å)
Cite:Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
IUCrJ, 5, 2018
1L9K
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BU of 1l9k by Molmil
dengue methyltransferase
Descriptor: RNA-DIRECTED RNA POLYMERASE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Egloff, M.P, Benarroch, D, Selisko, B, Romette, J.L, Canard, B.
Deposit date:2002-03-25
Release date:2003-03-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21, 2002
1MN9
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BU of 1mn9 by Molmil
NDP kinase mutant (H122G) complex with RTP
Descriptor: MAGNESIUM ION, NDP kinase, RIBAVIRIN TRIPHOSPHATE
Authors:Gallois-montbrun, S, Chen, Y, Dutartre, H, Morera, S, Guerreiro, C, Mulard, L, Schneider, B, Janin, J, Canard, B, Veron, M, Deville-bonne, D.
Deposit date:2002-09-05
Release date:2003-03-18
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets
MOL.PHARMACOL., 63, 2003
1F3F
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BU of 1f3f by Molmil
STRUCTURE OF THE H122G NUCLEOSIDE DIPHOSPHATE KINASE / D4T-TRIPHOSPHATE.MG COMPLEX
Descriptor: 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-DIPHOSPHATE, 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Meyer, P, Schneider, B, Sarfati, S, Deville-Bonne, D, Guerreiro, C, Boretto, J, Janin, J, Veron, M, Canard, B.
Deposit date:2000-06-02
Release date:2000-09-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
7Z2J
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BU of 7z2j by Molmil
White Bream virus N7-Methyltransferase
Descriptor: Non-structural protein 1, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Shannon, A, Gauffre, P, Canard, B, Ferron, F.
Deposit date:2022-02-28
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.657 Å)
Cite:A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome.
Nucleic Acids Res., 50, 2022
1F6T
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BU of 1f6t by Molmil
STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX
Descriptor: 2*-DEOXY-THYMIDINE-5*-ALPHA BORANO DIPHOSPHATE (ISOMER RP), MAGNESIUM ION, PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE)
Authors:Guerreiro, C, Boretto, J, Janin, J, Veron, M, Canard, B, Schneider, B, Sarfati, S, Deville-Bonne, D.
Deposit date:2000-06-23
Release date:2000-09-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
7Z05
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BU of 7z05 by Molmil
White Bream virus N7-Methyltransferase
Descriptor: DI(HYDROXYETHYL)ETHER, Non-structural protein 1, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Shannon, A, Gauffre, P, Canard, B, Ferron, F.
Deposit date:2022-02-22
Release date:2022-09-28
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome.
Nucleic Acids Res., 50, 2022
5FVA
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BU of 5fva by Molmil
Toscana Virus Nucleocapsid Protein
Descriptor: NUCLEOPROTEIN, SODIUM ION
Authors:Baklouti, A, Sevajol, M, Goulet, A, Lichiere, J, Ferron, F, Canard, B, Charrel, R.N, Coutard, B, Papageorgiou, N.
Deposit date:2016-02-03
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Toscana virus nucleoprotein oligomer organization observed in solution.
Acta Crystallogr D Struct Biol, 73, 2017
2XYQ
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BU of 2xyq by Molmil
Crystal structure of the nsp16 nsp10 SARS coronavirus complex
Descriptor: CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ...
Authors:Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B.
Deposit date:2010-11-18
Release date:2011-10-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
2XYV
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BU of 2xyv by Molmil
Crystal structure of the nsp16 nsp10 SARS coronavirus complex
Descriptor: CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ...
Authors:Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B.
Deposit date:2010-11-19
Release date:2011-10-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011

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