1F3F

STRUCTURE OF THE H122G NUCLEOSIDE DIPHOSPHATE KINASE / D4T-TRIPHOSPHATE.MG COMPLEX

Summary for 1F3F

DescriptorPROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE), MAGNESIUM ION, 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywordsnucleoside diphosphate kinase, anti-hiv nucleoside analogue, phosphorylation, ch...o bond, transferase
Biological sourceDictyostelium discoideum
Cellular locationCytoplasm P22887
Total number of polymer chains3
Total molecular weight52150.24
Authors
Meyer, P.,Schneider, B.,Sarfati, S.,Deville-Bonne, D.,Guerreiro, C.,Boretto, J.,Janin, J.,Veron, M.,Canard, B. (deposition date: 2000-06-02, release date: 2000-09-13, Last modification date: 2011-07-13)
Primary citation
Meyer, P.,Schneider, B.,Sarfati, S.,Deville-Bonne, D.,Guerreiro, C.,Boretto, J.,Janin, J.,Veron, M.,Canard, B.
Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19:3520-3529, 2000
PubMed: 10899107 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/19.14.3520
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1102.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report