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4V43
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BU of 4v43 by Molmil
Structural and mechanistic basis for allostery in the bacterial chaperonin GroEL
Descriptor: GROEL PROTEIN
Authors:Wang, J.
Deposit date:2002-01-02
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:A GroEL/GroES complex structure revisited: the structure-based mechanism of ATP hydrolysis
To be Published
8I4Z
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BU of 8i4z by Molmil
CalA3 with hydrolysis product
Descriptor: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I
Authors:Wang, J, Wang, Z.
Deposit date:2023-01-21
Release date:2023-02-22
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
8I4Y
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BU of 8i4y by Molmil
CalA3 complex structure with amidation product
Descriptor: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I
Authors:Wang, J, Wang, Z.
Deposit date:2023-01-21
Release date:2023-02-22
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
8HW4
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BU of 8hw4 by Molmil
Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs
Descriptor: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3
Authors:Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
Deposit date:2022-12-28
Release date:2023-06-07
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8HVH
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BU of 8hvh by Molmil
Cryo-EM structure of ABC transporter ABCC3
Descriptor: ATP-binding cassette sub-family C member 3
Authors:Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
Deposit date:2022-12-26
Release date:2023-06-07
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8HW2
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BU of 8hw2 by Molmil
Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs
Descriptor: ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide
Authors:Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
Deposit date:2022-12-28
Release date:2023-06-07
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
7T02
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BU of 7t02 by Molmil
Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM
Descriptor: DNA (5'-D(*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ...
Authors:Wang, J, Patel, D.J.
Deposit date:2021-11-29
Release date:2022-02-23
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
Mol.Cell, 82, 2022
7SXO
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BU of 7sxo by Molmil
Yeast Lon (PIM1) with endogenous substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ...
Authors:Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C.
Deposit date:2021-11-24
Release date:2022-01-12
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.
J.Biol.Chem., 298, 2022
6CWB
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BU of 6cwb by Molmil
Structure of alpha-GSA[8,4P] bound by CD1d and in complex with the Va14Vb8.2 TCR
Descriptor: (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-[(1E)-4-phenylbutylidene]-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, J, Zajonc, D.
Deposit date:2018-03-30
Release date:2019-04-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides.
J.Biol.Chem., 294, 2019
6CX5
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BU of 6cx5 by Molmil
Structure of alpha-GSA[8,8P] bound by CD1d and in complex with the Va14Vb8.2 TCR
Descriptor: (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-(8-phenyloctyl)-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, J, Zajonc, D.
Deposit date:2018-04-02
Release date:2019-04-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides.
J.Biol.Chem., 294, 2019
6CW9
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BU of 6cw9 by Molmil
Structure of alpha-GC[8,16P] bound by CD1d and in complex with the Va14Vb8.2 TCR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, J, Zajonc, D.
Deposit date:2018-03-30
Release date:2019-04-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides.
J.Biol.Chem., 294, 2019
6CX9
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BU of 6cx9 by Molmil
Structure of alpha-GSA[16,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ...
Authors:Wang, J, Zajonc, D.
Deposit date:2018-04-02
Release date:2019-04-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides.
J.Biol.Chem., 294, 2019
6CX7
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BU of 6cx7 by Molmil
Structure of alpha-GSA[12,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ...
Authors:Wang, J, Zajonc, D.
Deposit date:2018-04-02
Release date:2019-04-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides.
J.Biol.Chem., 294, 2019
1Y6V
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BU of 1y6v by Molmil
Structure of E. coli Alkaline Phosphatase in presence of cobalt at 1.60 A resolution
Descriptor: Alkaline phosphatase, COBALT (II) ION, PHOSPHATE ION, ...
Authors:Wang, J, Stieglitz, K, Kantrowitz, E.R.
Deposit date:2004-12-07
Release date:2005-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
Biochemistry, 44, 2005
1Y5R
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BU of 1y5r by Molmil
The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone
Descriptor: CORTICOSTERONE, Corticosteroid 11-beta-dehydrogenase, isozyme 1, ...
Authors:Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S.
Deposit date:2004-12-02
Release date:2005-05-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Biochemistry, 44, 2005
1Y5M
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BU of 1y5m by Molmil
The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes
Descriptor: Corticosteroid 11-beta-dehydrogenase, isozyme 1, N-OCTANE, ...
Authors:Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S.R.
Deposit date:2004-12-02
Release date:2005-05-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Biochemistry, 44, 2005
1Y7A
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BU of 1y7a by Molmil
Structure of D153H/K328W E. coli alkaline phosphatase in presence of cobalt at 1.77 A resolution
Descriptor: Alkaline phosphatase, COBALT (II) ION, PHOSPHATE ION, ...
Authors:Wang, J, Stieglitz, K, Kantrowitz, E.R.
Deposit date:2004-12-08
Release date:2005-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
Biochemistry, 44, 2005
5LP6
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BU of 5lp6 by Molmil
Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Marangon, J, Christodoulou, M, Casagrande, F, Tiana, G, Dalla Via, L, Aliverti, A, Passarella, D, Cappelletti, G, Ricagno, S.
Deposit date:2016-08-11
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Tools for the rational design of bivalent microtubule-targeting drugs.
Biochem. Biophys. Res. Commun., 479, 2016
8ZFT
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BU of 8zft by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and SR1664
Descriptor: 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 4'-[(2,3-dimethyl-5-{[(1S)-1-(4-nitrophenyl)ethyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2024-05-08
Release date:2024-08-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
Elife, 2024
8ZFO
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BU of 8zfo by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and nTZDpa
Descriptor: 2-chloro-5-nitro-N-phenylbenzamide, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2024-05-08
Release date:2024-08-07
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
Elife, 2024
8ZFP
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BU of 8zfp by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and MRL24
Descriptor: (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID, 2-chloro-5-nitro-N-phenylbenzamide, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2024-05-08
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
Elife, 2024
8ZFQ
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BU of 8zfq by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and BVT.13
Descriptor: 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2024-05-08
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
Elife, 2024
8ZFS
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BU of 8zfs by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and MRL24
Descriptor: (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2024-05-08
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
Elife, 2024
8ZFN
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BU of 8zfn by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and BVT.13
Descriptor: 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, 2-chloro-5-nitro-N-phenylbenzamide, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2024-05-08
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
Elife, 2024
8ZFR
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BU of 8zfr by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and nTZDpa
Descriptor: 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2024-05-08
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
Elife, 2024

224931

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