7T02
Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM
Summary for 7T02
| Entry DOI | 10.2210/pdb7t02/pdb |
| Related | 7R76 7R77 7R78 |
| EMDB information | 25577 |
| Descriptor | DNA repair protein Rad8, DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), ... (4 entities in total) |
| Functional Keywords | cytosine-5 methyltransferase, snf2 atpase, transferase, hemimethylated dna, transferase-dna complex, transferase/dna |
| Biological source | Cryptococcus neoformans var. grubii H99 More |
| Total number of polymer chains | 3 |
| Total formula weight | 286305.99 |
| Authors | Wang, J.,Patel, D.J. (deposition date: 2021-11-29, release date: 2022-02-23, Last modification date: 2024-02-28) |
| Primary citation | Wang, J.,Catania, S.,Wang, C.,de la Cruz, M.J.,Rao, B.,Madhani, H.D.,Patel, D.J. Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82:1186-1198.e6, 2022 Cited by PubMed: 35202575DOI: 10.1016/j.molcel.2022.01.028 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
Download full validation report
