5T7V
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![BU of 5t7v by Molmil](/molmil-images/mine/5t7v) | Methicillin Resistant, Linezolid resistant Staphylococcus aureus 70S ribosome (delta S145 uL3) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Belousoff, M.J, Lithgow, T, Eyal, Z, Yonath, A, Radjainia, M. | Deposit date: | 2016-09-06 | Release date: | 2017-05-31 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Basis for Linezolid Binding Site Rearrangement in theStaphylococcus aureusRibosome. MBio, 8, 2017
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5TDK
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![BU of 5tdk by Molmil](/molmil-images/mine/5tdk) | RNA decamer duplex with eight 2'-5'-linkages | Descriptor: | RNA (5'-R(*CP*CP*GP*GP*CP*GP*CP*CP*GP*G)-3'), STRONTIUM ION | Authors: | Luo, Z, Sheng, J. | Deposit date: | 2016-09-19 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Structural insights into RNA duplexes with multiple 2 -5 -linkages. Nucleic Acids Res., 45, 2017
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6XCU
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![BU of 6xcu by Molmil](/molmil-images/mine/6xcu) | |
8JKM
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![BU of 8jkm by Molmil](/molmil-images/mine/8jkm) | RN-1747 bound state of mTRPV4 | Descriptor: | Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-06-01 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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7T2P
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![BU of 7t2p by Molmil](/molmil-images/mine/7t2p) | |
7T4G
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2RJZ
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![BU of 2rjz by Molmil](/molmil-images/mine/2rjz) | Crystal structure of the type 4 fimbrial biogenesis protein PilO from Pseudomonas aeruginosa | Descriptor: | PilO protein, SULFATE ION | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Chang, S, Ozyurt, S, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-10-16 | Release date: | 2007-11-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex. J.Mol.Biol., 394, 2009
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6EZ2
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![BU of 6ez2 by Molmil](/molmil-images/mine/6ez2) | Human butyrylcholinesterase carbamylated. | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Brazzolotto, X, de la Mora, E, Dighe, S.N, Ross, B.P. | Deposit date: | 2017-11-14 | Release date: | 2018-12-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model. Commun Chem, 2019
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7VVW
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![BU of 7vvw by Molmil](/molmil-images/mine/7vvw) | MmtN-SAM complex | Descriptor: | GLYCEROL, PHOSPHATE ION, S-ADENOSYLMETHIONINE, ... | Authors: | Zhang, Y.Z, Peng, M, Li, C.Y. | Deposit date: | 2021-11-09 | Release date: | 2022-04-20 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Insights into methionine S-methylation in diverse organisms. Nat Commun, 13, 2022
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7VVV
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![BU of 7vvv by Molmil](/molmil-images/mine/7vvv) | Crystal structure of MmtN | Descriptor: | PHOSPHATE ION, SAM-dependent methyltransferase | Authors: | Peng, M, Li, C.Y. | Deposit date: | 2021-11-09 | Release date: | 2022-04-20 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Insights into methionine S-methylation in diverse organisms. Nat Commun, 13, 2022
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7VVX
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![BU of 7vvx by Molmil](/molmil-images/mine/7vvx) | MmtN-SAH-Met complex | Descriptor: | METHIONINE, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Zhang, Y.Z, Peng, M, Li, C.Y. | Deposit date: | 2021-11-09 | Release date: | 2022-04-20 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Insights into methionine S-methylation in diverse organisms. Nat Commun, 13, 2022
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5TDJ
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![BU of 5tdj by Molmil](/molmil-images/mine/5tdj) | RNA decamer duplex with four 2'-5'-linkages | Descriptor: | RNA (5'-R(*CP*CP*GP*GP*CP*GP*CP*CP*GP*G)-3'), STRONTIUM ION | Authors: | Luo, Z, Sheng, J. | Deposit date: | 2016-09-19 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural insights into RNA duplexes with multiple 2 -5 -linkages. Nucleic Acids Res., 45, 2017
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5WXC
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![BU of 5wxc by Molmil](/molmil-images/mine/5wxc) | Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 2) | Descriptor: | Beta-2-microglobulin, H7-25-F, HLA class I histocompatibility antigen, ... | Authors: | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2017-01-07 | Release date: | 2018-01-17 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (2.295 Å) | Cite: | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio, 9, 2018
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6Z45
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![BU of 6z45 by Molmil](/molmil-images/mine/6z45) | CDK9-Cyclin-T1 complex bound by compound 24 | Descriptor: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | Authors: | Ferguson, A, Collie, G.W. | Deposit date: | 2020-05-22 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.37 Å) | Cite: | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
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3DG6
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![BU of 3dg6 by Molmil](/molmil-images/mine/3dg6) | Crystal structure of muconate lactonizing enzyme from Mucobacterium Smegmatis complexed with muconolactone | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase, [(2S)-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | Authors: | Fedorov, A.A, Fedorov, E.V, Sakai, A, Gerlt, J.A, Almo, S.C. | Deposit date: | 2008-06-12 | Release date: | 2009-03-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes Biochemistry, 48, 2009
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3DG7
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![BU of 3dg7 by Molmil](/molmil-images/mine/3dg7) | Crystal structure of muconate lactonizing enzyme from Mucobacterium Smegmatis complexed with muconolactone | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase, [(2S)-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | Authors: | Fedorov, A.A, Fedorov, E.V, Sakai, A, Gerlt, J.A, Almo, S.C. | Deposit date: | 2008-06-12 | Release date: | 2009-03-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes Biochemistry, 48, 2009
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5XYF
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![BU of 5xyf by Molmil](/molmil-images/mine/5xyf) | Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex | Descriptor: | Adrenocortical dysplasia protein homolog, TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2 | Authors: | Hu, C, Chen, Y. | Deposit date: | 2017-07-07 | Release date: | 2017-12-13 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex. Cell Res., 27, 2017
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6EUE
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![BU of 6eue by Molmil](/molmil-images/mine/6eue) | Rivastigmine analogue bound to Tc ACHE. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, PENTAETHYLENE GLYCOL | Authors: | De la Mora, E, Brazzolotto, X, Dighe, S.N, Silman, I, Weik, M, Ross, B. | Deposit date: | 2017-10-30 | Release date: | 2018-11-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model Commun Chem, 2019
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3DGB
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![BU of 3dgb by Molmil](/molmil-images/mine/3dgb) | Crystal structure of muconate lactonizing enzyme from Pseudomonas Fluorescens complexed with muconolactone | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase, [(2S)-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | Authors: | Fedorov, A.A, Fedorov, E.V, Sauder, J.M, Burley, S.K, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-06-13 | Release date: | 2009-03-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes Biochemistry, 48, 2009
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3DG3
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![BU of 3dg3 by Molmil](/molmil-images/mine/3dg3) | Crystal structure of muconate lactonizing enzyme from Mucobacterium Smegmatis | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase | Authors: | Fedorov, A.A, Fedorov, E.V, Sakai, A, Gerlt, J.A, Almo, S.C. | Deposit date: | 2008-06-12 | Release date: | 2009-03-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes Biochemistry, 48, 2009
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8J1F
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![BU of 8j1f by Molmil](/molmil-images/mine/8j1f) | GSK101 bound state of mTRPV4 | Descriptor: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1D
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![BU of 8j1d by Molmil](/molmil-images/mine/8j1d) | Cryo-EM structure of apo state mTRPV4 | Descriptor: | Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1H
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![BU of 8j1h by Molmil](/molmil-images/mine/8j1h) | Agonist1 and Ruthenium Red bound state of mTRPV4 | Descriptor: | 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one, Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1B
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![BU of 8j1b by Molmil](/molmil-images/mine/8j1b) | GSK101 and Ruthenium Red bound state of mTRPV4 | Descriptor: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8QW7
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![BU of 8qw7 by Molmil](/molmil-images/mine/8qw7) | Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB | Descriptor: | (2S,4R)-1-[(2R)-2-[3-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Zollman, D, Farnaby, W, Ciulli, A. | Deposit date: | 2023-10-18 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
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