7AS3
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![BU of 7as3 by Molmil](/molmil-images/mine/7as3) | Influenza A PB2 (H357N mutation) in complex with VX-787 | Descriptor: | (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2 | Authors: | Radilova, K, Brynda, J. | Deposit date: | 2020-10-26 | Release date: | 2021-02-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase. Molecules, 26, 2021
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1YW1
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5BPX
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![BU of 5bpx by Molmil](/molmil-images/mine/5bpx) | Structure of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP. | Descriptor: | 2,4'-dihydroxyacetophenone dioxygenase, ACETATE ION, FE (III) ION, ... | Authors: | Guo, J, Erskine, P, Wood, S.P, Cooper, J.B. | Deposit date: | 2015-05-28 | Release date: | 2015-06-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Extension of resolution and oligomerization-state studies of 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP. Acta Crystallogr.,Sect.F, 71, 2015
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6CEZ
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![BU of 6cez by Molmil](/molmil-images/mine/6cez) | Crystal Structure of Rabbit Anti-HIV-1 gp120 V2 Fab 16C2 in complex with V2 peptide ConB | Descriptor: | HIV-1 gp120 V2 Peptide Con B, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V2 mAb 16C2, Light chain of Fab fragment of rabbit anti-HIV1 gp120 V2 mAb 16C2 | Authors: | Kong, X, Pan, R. | Deposit date: | 2018-02-13 | Release date: | 2018-09-12 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha 4 beta 7. PLoS Pathog., 14, 2018
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5UTF
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![BU of 5utf by Molmil](/molmil-images/mine/5utf) | Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35022 Heavy chain, ... | Authors: | Pancera, M, Chuang, G.-Y, Xu, K, Kwong, P.D. | Deposit date: | 2017-02-14 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. J. Virol., 91, 2017
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6XM0
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![BU of 6xm0 by Molmil](/molmil-images/mine/6xm0) | Consensus structure of SARS-CoV-2 spike at pH 5.5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | Deposit date: | 2020-06-29 | Release date: | 2020-08-12 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6XLU
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![BU of 6xlu by Molmil](/molmil-images/mine/6xlu) | Structure of SARS-CoV-2 spike at pH 4.0 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | Deposit date: | 2020-06-29 | Release date: | 2020-08-12 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6XM3
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![BU of 6xm3 by Molmil](/molmil-images/mine/6xm3) | Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | Deposit date: | 2020-06-29 | Release date: | 2020-08-12 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6XM5
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![BU of 6xm5 by Molmil](/molmil-images/mine/6xm5) | Structure of SARS-CoV-2 spike at pH 5.5, all RBDs down | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | Deposit date: | 2020-06-29 | Release date: | 2020-07-29 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6XEY
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![BU of 6xey by Molmil](/molmil-images/mine/6xey) | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4 | Descriptor: | 2-4 Heavy Chain, 2-4 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rapp, M, Shapiro, L, Ho, D.D. | Deposit date: | 2020-06-14 | Release date: | 2020-07-22 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature, 584, 2020
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6XM4
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![BU of 6xm4 by Molmil](/molmil-images/mine/6xm4) | Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | Deposit date: | 2020-06-29 | Release date: | 2020-08-12 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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4TVP
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![BU of 4tvp by Molmil](/molmil-images/mine/4tvp) | Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... | Authors: | Pancera, M, Zhou, T, Kwong, P.D. | Deposit date: | 2014-06-27 | Release date: | 2014-10-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature, 514, 2014
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8OOJ
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![BU of 8ooj by Molmil](/molmil-images/mine/8ooj) | Crystal structure of dCK C4S-S74E mutant in complex with EdC and UDP | Descriptor: | 4-azanyl-1-[(2~{R},4~{S},5~{R})-5-ethynyl-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]pyrimidin-2-one, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | Authors: | Saez-Ayala, M, Rebuffet, E, Betzi, S, Morelli, X. | Deposit date: | 2023-04-05 | Release date: | 2023-12-20 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | 4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress. Mol.Cancer Ther., 23, 2024
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8GIU
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![BU of 8giu by Molmil](/molmil-images/mine/8giu) | Mycobacterium phage Patience | Descriptor: | Capsid protein, gp_22 (Minor Capsid Protein), gp_4 (capsid accessory protein) | Authors: | Podgorski, J.M, White, S.J. | Deposit date: | 2023-03-14 | Release date: | 2023-05-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | A novel accessory protein stabilizes the capsid of two actinobacteriophages To Be Published
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6XCJ
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![BU of 6xcj by Molmil](/molmil-images/mine/6xcj) | Crystal Structure of DH650 Fab from a Rhesus Macaque in Complex with HIV-1 gp120 Core | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DH650 Fab Heavy Chain, DH650 Fab Light Chain, ... | Authors: | Raymond, D.D, Chug, H, Harrison, S.C. | Deposit date: | 2020-06-08 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science, 371, 2021
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1ZOM
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![BU of 1zom by Molmil](/molmil-images/mine/1zom) | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomimetic Inhibitor | Descriptor: | (S)-2-(3-((R)-1-(4-BROMOPHENYL)ETHYL)UREIDO)-N-((S)-1-((S)-5-GUANIDINO-1-OXO-1-(THIAZOL-2-YL)PENTAN-2-YLAMINO)-3-METHYL-1-OXOBUTAN-2-YL)-5-UREIDOPENTANAMIDE, Coagulation factor XI, SULFATE ION | Authors: | Lin, J, Deng, H, Jin, L, Pandey, P, Rynkiewicz, M, Bibbins, F, Cantin, S, Quinn, J, Magee, S, Gorga, J. | Deposit date: | 2005-05-13 | Release date: | 2006-05-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants. J.Med.Chem., 49, 2006
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7S01
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![BU of 7s01 by Molmil](/molmil-images/mine/7s01) | X-ray structure of the phage AR9 non-virion RNA polymerase holoenzyme in complex with a forked oligonucleotide containing the P077 promoter | Descriptor: | DNA-directed RNA polymerase, DNA-directed RNA polymerase beta subunit, DNA-directed RNA polymerase beta' subunit, ... | Authors: | Leiman, P.G, Sokolova, M.L, Gordeeva, J, Fraser, A, Severinov, K.V. | Deposit date: | 2021-08-28 | Release date: | 2022-07-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase. Nat Commun, 13, 2022
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6MTQ
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![BU of 6mtq by Molmil](/molmil-images/mine/6mtq) | Crystal structure of VRC42.N1 Fab in complex with T117-F MPER scaffold | Descriptor: | Antibody VRC42.N1 Fab heavy chain, Antibody VRC42.N1 Fab light chain, VRC42 epitope T117-F scaffold | Authors: | Kwon, Y.D, Law, W.H, Veradi, R, Doria-Rose, N.A, Kwong, P.D. | Deposit date: | 2018-10-21 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
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6MQE
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![BU of 6mqe by Molmil](/molmil-images/mine/6mqe) | |
6MQS
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![BU of 6mqs by Molmil](/molmil-images/mine/6mqs) | |
8G4M
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![BU of 8g4m by Molmil](/molmil-images/mine/8g4m) | Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Wang, S, Morano, N.C, Shapiro, L, Kwong, P.D. | Deposit date: | 2023-02-10 | Release date: | 2023-07-12 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide. Cell Rep, 42, 2023
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8G4T
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![BU of 8g4t by Molmil](/molmil-images/mine/8g4t) | Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein BG505 DS-SOSIP gp120, ... | Authors: | Wang, S, Kwong, P.D. | Deposit date: | 2023-02-10 | Release date: | 2023-07-12 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide. Cell Rep, 42, 2023
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8SAJ
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![BU of 8saj by Molmil](/molmil-images/mine/8saj) | Mycobacterium phage Adjutor | Descriptor: | HNH endonuclease, Major capsid protein, gp_16 (Minor Capsid Protein) | Authors: | Podgorski, J.M, White, S.J. | Deposit date: | 2023-04-01 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | A novel accessory protein stabilizes the capsid of two actinobacteriophages To Be Published
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7MD4
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![BU of 7md4 by Molmil](/molmil-images/mine/7md4) | Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists | Descriptor: | Insulin B chain, Insulin chain A, Isoform Short of Insulin receptor, ... | Authors: | Gomez-Llorente, Y, Zhou, H, Scapin, G. | Deposit date: | 2021-04-03 | Release date: | 2022-02-23 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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7MD5
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![BU of 7md5 by Molmil](/molmil-images/mine/7md5) | Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gomez-Llorente, Y, Zhou, H, Scapin, G. | Deposit date: | 2021-04-03 | Release date: | 2022-02-23 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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