1ZOM

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomimetic Inhibitor

Summary for 1ZOM

Entry DOI	10.2210/pdb1zom/pdb
Descriptor	Coagulation factor XI, SULFATE ION, (S)-2-(3-((R)-1-(4-BROMOPHENYL)ETHYL)UREIDO)-N-((S)-1-((S)-5-GUANIDINO-1-OXO-1-(THIAZOL-2-YL)PENTAN-2-YLAMINO)-3-METHYL-1-OXOBUTAN-2-YL)-5-UREIDOPENTANAMIDE, ... (4 entities in total)
Functional Keywords	fxia, inhibitor, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P03951
Total number of polymer chains	1
Total formula weight	27574.13
Authors	Lin, J.,Deng, H.,Jin, L.,Pandey, P.,Rynkiewicz, M.,Bibbins, F.,Cantin, S.,Quinn, J.,Magee, S.,Gorga, J. (deposition date: 2005-05-13, release date: 2006-05-23, Last modification date: 2023-08-23)
Primary citation	Lin, J.,Deng, H.,Jin, L.,Pandey, P.,Quinn, J.,Cantin, S.,Rynkiewicz, M.J.,Gorga, J.C.,Bibbins, F.,Celatka, C.A.,Nagafuji, P.,Bannister, T.D.,Meyers, H.V.,Babine, R.E.,Hayward, N.J.,Weaver, D.,Benjamin, H.,Stassen, F.,Abdel-Meguid, S.S.,Strickler, J.E. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants. J.Med.Chem., 49:7781-7791, 2006 Cited by PubMed: 17181160 DOI: 10.1021/jm060978s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation