7WKX
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![BU of 7wkx by Molmil](/molmil-images/mine/7wkx) | IL-17A in complex with the humanized antibody HB0017 | Descriptor: | ACETIC ACID, Heavy chain of HB0017 Fab, Interleukin-17A, ... | Authors: | Xu, J, Zhu, X, He, Y. | Deposit date: | 2022-01-12 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases. Int.J.Biol.Macromol., 202, 2022
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8INZ
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![BU of 8inz by Molmil](/molmil-images/mine/8inz) | Cryo-EM structure of human HCN3 channel in apo state | Descriptor: | 4-[[(2~{S},4~{a}~{R},6~{S},8~{a}~{S})-6-[(4~{S},5~{R})-4-[(2~{S})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{H}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Authors: | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | Deposit date: | 2023-03-10 | Release date: | 2024-04-10 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J.Biol.Chem., 300, 2024
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2ILV
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![BU of 2ilv by Molmil](/molmil-images/mine/2ilv) | |
2IIB
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![BU of 2iib by Molmil](/molmil-images/mine/2iib) | |
2IHJ
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![BU of 2ihj by Molmil](/molmil-images/mine/2ihj) | |
2IIQ
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![BU of 2iiq by Molmil](/molmil-images/mine/2iiq) | |
2IHZ
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![BU of 2ihz by Molmil](/molmil-images/mine/2ihz) | |
2II6
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![BU of 2ii6 by Molmil](/molmil-images/mine/2ii6) | |
2NQ3
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![BU of 2nq3 by Molmil](/molmil-images/mine/2nq3) | Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase | Descriptor: | CHLORIDE ION, Itchy homolog E3 ubiquitin protein ligase | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-10-30 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase To be Published
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8WXV
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![BU of 8wxv by Molmil](/molmil-images/mine/8wxv) | |
8WXX
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8X0S
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![BU of 8x0s by Molmil](/molmil-images/mine/8x0s) | Crystal structure of r(G4C2)2 | Descriptor: | POTASSIUM ION, RNA (5'-R(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*C)-3') | Authors: | Geng, Y, Liu, C, Cai, Q, Zhu, G. | Deposit date: | 2023-11-05 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.956 Å) | Cite: | Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD. Nucleic Acids Res., 2024
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8W2R
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![BU of 8w2r by Molmil](/molmil-images/mine/8w2r) | HIV-1 P5-IN intasome core | Descriptor: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ... | Authors: | Li, M, Craigie, R. | Deposit date: | 2024-02-21 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
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8WXT
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8XJ3
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![BU of 8xj3 by Molmil](/molmil-images/mine/8xj3) | |
8WXQ
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![BU of 8wxq by Molmil](/molmil-images/mine/8wxq) | Structure of WDR5 in complex with WIN motif containing MBD3C | Descriptor: | GLY-ALA-ALA-ARG-CYS-ARG-VAL-PHE-SER-PRO, WD repeat-containing protein 5 | Authors: | Xu, L, Yang, Y. | Deposit date: | 2023-10-30 | Release date: | 2024-06-26 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural studies of WDR5 in complex with MBD3C WIN motif reveal a unique binding mode. J.Biol.Chem., 300, 2024
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8W34
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![BU of 8w34 by Molmil](/molmil-images/mine/8w34) | HIV-1 intasome core assembled with wild-type integrase, 1F | Descriptor: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ... | Authors: | Li, M, Craigie, R. | Deposit date: | 2024-02-21 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
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8WXU
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8W09
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![BU of 8w09 by Molmil](/molmil-images/mine/8w09) | HIV-1 wild-type intasome core | Descriptor: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ... | Authors: | Li, M, Craigie, R. | Deposit date: | 2024-02-13 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
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8FQ7
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![BU of 8fq7 by Molmil](/molmil-images/mine/8fq7) | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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8WXR
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5E5W
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![BU of 5e5w by Molmil](/molmil-images/mine/5e5w) | Hemagglutinin-esterase-fusion mutant structure of influenza D virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin-esterase, ... | Authors: | Song, H, Qi, J, Shi, Y, Gao, G.F. | Deposit date: | 2015-10-09 | Release date: | 2016-03-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism PLoS Pathog., 12, 2016
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8GVJ
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![BU of 8gvj by Molmil](/molmil-images/mine/8gvj) | Crystal structure of cMET kinase domain bound by D6808 | Descriptor: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | Authors: | Chen, Y.H, Qu, L.Z. | Deposit date: | 2022-09-15 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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5E65
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![BU of 5e65 by Molmil](/molmil-images/mine/5e65) | The complex structure of Hemagglutinin-esterase-fusion mutant protein from the influenza D virus with receptor analog 9-O-Ac-3'SLN (Tr322) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-O-acetyl-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid-(2-3)-beta-D-galactopyranose, ... | Authors: | Song, H, Qi, J, Shi, Y, Gao, G.F. | Deposit date: | 2015-10-09 | Release date: | 2016-03-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism PLoS Pathog., 12, 2016
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4OM0
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![BU of 4om0 by Molmil](/molmil-images/mine/4om0) | |