5ZD0
 
 | | Solution structure of human ubiquitin with three alanine mutations in living eukaryotic cells by in-cell NMR spectroscopy | | Descriptor: | ubiquitin | | Authors: | Tanaka, T, Ikeya, T, Kamoshida, H, Mishima, M, Shirakawa, M, Guentert, P, Ito, Y. | | Deposit date: | 2018-02-22 | | Release date: | 2019-08-21 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells.
Angew.Chem.Int.Ed.Engl., 58, 2019
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5Z4B
 | | GB1 structure determination in living eukaryotic cells by in-cell NMR spectroscopy | | Descriptor: | Protein LG | | Authors: | Tanaka, T, Teppei, I, Kamoshida, H, Mishima, M, Shirakawa, M, Guentert, P, Ito, Y. | | Deposit date: | 2018-01-10 | | Release date: | 2019-01-23 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells.
Angew.Chem.Int.Ed.Engl., 58, 2019
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3WO2
 | | Crystal structure of human interleukin-18 | | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION | | Authors: | Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. | | Deposit date: | 2013-12-19 | | Release date: | 2014-12-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
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3WO4
 | | Crystal structure of the IL-18 signaling ternary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. | | Deposit date: | 2013-12-19 | | Release date: | 2014-12-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
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3WO3
 | | Crystal structure of IL-18 in complex with IL-18 receptor alpha | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. | | Deposit date: | 2013-12-19 | | Release date: | 2014-12-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
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1NFT
 | | OVOTRANSFERRIN, N-TERMINAL LOBE, IRON LOADED OPEN FORM | | Descriptor: | FE (III) ION, NITRILOTRIACETIC ACID, PROTEIN (OVOTRANSFERRIN), ... | | Authors: | Mizutani, K, Yamashita, H, Kurokawa, H, Mikami, B, Hirose, M. | | Deposit date: | 1999-01-07 | | Release date: | 1999-01-13 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Alternative structural state of transferrin. The crystallographic analysis of iron-loaded but domain-opened ovotransferrin N-lobe.
J.Biol.Chem., 274, 1999
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1AMS
 | | X-RAY CRYSTALLOGRAPHIC STUDY OF PYRIDOXAMINE 5'-PHOSPHATE-TYPE ASPARTATE AMINOTRANSFERASES FROM ESCHERICHIA COLI IN THREE FORMS | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE, GLUTARIC ACID | | Authors: | Miyahara, I, Hirotsu, K, Hayashi, H, Kagamiyama, H. | | Deposit date: | 1994-07-01 | | Release date: | 1994-09-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | X-ray crystallographic study of pyridoxamine 5'-phosphate-type aspartate aminotransferases from Escherichia coli in three forms.
J.Biochem.(Tokyo), 116, 1994
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7V6B
 | | Structure of the Dicer-2-R2D2 heterodimer | | Descriptor: | Dicer-2, isoform A, R2D2 | | Authors: | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | | Deposit date: | 2021-08-20 | | Release date: | 2022-03-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
Nature, 607, 2022
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7V6C
 | | Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex | | Descriptor: | Dicer-2, isoform A, R2D2, ... | | Authors: | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | | Deposit date: | 2021-08-20 | | Release date: | 2022-03-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
Nature, 607, 2022
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5H34
 | | Crystal structure of the C-terminal domain of methionyl-tRNA synthetase (MetRS-C) in Nanoarchaeum equitans | | Descriptor: | Methionine-tRNA ligase | | Authors: | Suzuki, H, Kaneko, A, Yamamoto, T, Nambo, M, Umehara, T, Yoshida, H, Park, S.Y, Tamura, K. | | Deposit date: | 2016-10-20 | | Release date: | 2017-06-21 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.748 Å) | | Cite: | Binding Properties of Split tRNA to the C-terminal Domain of Methionyl-tRNA Synthetase of Nanoarchaeum equitans.
J. Mol. Evol., 84, 2017
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3R1M
 | | Structure of bifunctional fructose 1,6-bisphosphate aldolase/phosphatase (aldolase form) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-DIHYDROXYACETONEPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Fushinobu, S, Nishimasu, H, Hattori, D, Song, H.-J, Wakagi, T. | | Deposit date: | 2011-03-10 | | Release date: | 2011-10-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase.
Nature, 478, 2011
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1NI6
 | | Comparisions of the Heme-Free and-Bound Crystal Structures of Human Heme Oxygenase-1 | | Descriptor: | CHLORIDE ION, Heme oxygenase 1, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose | | Authors: | Lad, L, Schuller, D.J, Friedman, J, Li, H, Shimizu, H, Ortiz de Montellano, P.R, Poulos, T.L. | | Deposit date: | 2002-12-21 | | Release date: | 2003-04-01 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1
J.Biol.Chem., 278, 2003
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1A3G
 | | BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE FROM ESCHERICHIA COLI | | Descriptor: | BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Okada, K, Hirotsu, K, Sato, M, Hayashi, H, Kagamiyama, H. | | Deposit date: | 1998-01-21 | | Release date: | 1998-05-27 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Three-dimensional structure of Escherichia coli branched-chain amino acid aminotransferase at 2.5 A resolution.
J.Biochem.(Tokyo), 121, 1997
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1AMR
 | | X-RAY CRYSTALLOGRAPHIC STUDY OF PYRIDOXAMINE 5'-PHOSPHATE-TYPE ASPARTATE AMINOTRANSFERASES FROM ESCHERICHIA COLI IN THREE FORMS | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE, MALEIC ACID | | Authors: | Miyahara, I, Hirotsu, K, Hayashi, H, Kagamiyama, H. | | Deposit date: | 1994-07-01 | | Release date: | 1994-09-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | X-ray crystallographic study of pyridoxamine 5'-phosphate-type aspartate aminotransferases from Escherichia coli in three forms.
J.Biochem.(Tokyo), 116, 1994
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7DEN
 | | Crystal structure of P.aeruginosa LpxC in complex with inhibitor | | Descriptor: | 4-[(1~{R},5~{S})-6-[2-[4-[3-[[2-[(1~{S})-1-oxidanylethyl]imidazol-1-yl]methyl]-1,2-oxazol-5-yl]phenyl]ethynyl]-3-azabicyclo[3.1.0]hexan-3-yl]butanoic acid, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | | Authors: | Mima, M, Ushiyama, F, Takashima, H. | | Deposit date: | 2020-11-04 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532.
Bioorg.Med.Chem., 30, 2020
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6IUE
 | | DNA helical wire containing Hg(II) | | Descriptor: | DNA (5'-D(*TP*TP*TP*GP*C)-3'), MERCURY (II) ION | | Authors: | Ono, A, Kanazawa, H, Ito, H, Goto, M, Nakamura, K, Saneyoshi, H, Kondo, J. | | Deposit date: | 2018-11-28 | | Release date: | 2019-10-16 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | A Novel DNA Helical Wire Containing HgII-Mediated T:T and T:G Pairs.
Angew.Chem.Int.Ed.Engl., 58, 2019
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1OM4
 | | STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUND | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ARGININE, ... | | Authors: | Li, H, Martasek, P, Shimizu, H, Masters, B.S.S, Poulos, T.L, Raman, C.S. | | Deposit date: | 2003-02-24 | | Release date: | 2003-03-11 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure of Rat Neuronal NOS Heme Domain with L-Arginine Bound
To be Published
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4GTX
 | | Crystal structure of mouse Enpp1 in complex with TMP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Kato, K, Nishimasu, H, Ishitani, R, Nureki, O. | | Deposit date: | 2012-08-29 | | Release date: | 2012-11-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.201 Å) | | Cite: | Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1AMQ
 | | X-RAY CRYSTALLOGRAPHIC STUDY OF PYRIDOXAMINE 5'-PHOSPHATE-TYPE ASPARTATE AMINOTRANSFERASES FROM ESCHERICHIA COLI IN THREE FORMS | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE | | Authors: | Miyahara, I, Hirotsu, K, Hayashi, H, Kagamiyama, H. | | Deposit date: | 1994-07-01 | | Release date: | 1994-09-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray crystallographic study of pyridoxamine 5'-phosphate-type aspartate aminotransferases from Escherichia coli in three forms.
J.Biochem.(Tokyo), 116, 1994
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5GSY
 | | Kinesin-8 motor, KIF19A, in the nucleotide-free state complexed with GDP-taxol microtubule | | Descriptor: | Kinesin-like protein KIF19 | | Authors: | Morikawa, M, Nitta, R, Yajima, H, Shigematsu, H, Kikkawa, M, Hirokawa, N. | | Deposit date: | 2016-08-17 | | Release date: | 2016-09-28 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
Elife, 5, 2016
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6D0D
 | | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13 | | Descriptor: | (3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}butan-2-yl]carbamate, Protease | | Authors: | Yedidi, R.S, Hayashi, H, Ghosh, A.K, Mitsuya, H. | | Deposit date: | 2018-04-10 | | Release date: | 2019-05-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications.
Antimicrob.Agents Chemother., 63, 2019
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7X5O
 | | Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly | | Descriptor: | N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, Serine hydroxymethyltransferase | | Authors: | Hasegawa, K, Hayashi, H. | | Deposit date: | 2022-03-05 | | Release date: | 2022-07-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.
Commun Biol, 5, 2022
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7X5N
 | | Crystal structure of E. faecium SHMT in complex with (+)-SHIN-1 and PLP-Ser | | Descriptor: | (4R)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1H-pyrano[2,3-c]pyrazole-5-carbonitrile, Serine hydroxymethyltransferase, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE | | Authors: | Hasegawa, K, Hayashi, H. | | Deposit date: | 2022-03-05 | | Release date: | 2022-07-06 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.
Commun Biol, 5, 2022
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1KOZ
 | | SOLUTION STRUCTURE OF OMEGA-GRAMMOTOXIN SIA | | Descriptor: | Voltage-dependent Channel Inhibitor | | Authors: | Takeuchi, K, Park, E.J, Lee, C.W, Kim, J.I, Takahashi, H, Swartz, K.J, Shimada, I. | | Deposit date: | 2001-12-25 | | Release date: | 2002-08-28 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel.
J.Mol.Biol., 321, 2002
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7C7L
 | | Cryo-EM structure of the Cas12f1-sgRNA-target DNA complex | | Descriptor: | CRISPR-associated protein Cas14a.1, DNA (40-mer), ZINC ION, ... | | Authors: | Takeda, N.S, Nakagawa, R, Okazaki, S, Hirano, H, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | | Deposit date: | 2020-05-26 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the miniature type V-F CRISPR-Cas effector enzyme.
Mol.Cell, 81, 2021
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