7X5O

Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly

Summary for 7X5O

• Entry DOI: 10.2210/pdb7x5o/pdb
• Related: 7V3D 7X5N
• Descriptor: Serine hydroxymethyltransferase, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ... (4 entities in total)
• Functional Keywords: e. faecium, serine hydroxymethyltransferase, 1c metabolism, transferase
• Biological source: Enterococcus faecium
• Total number of polymer chains: 2
• Total formula weight: 92000.86

Authors

Hasegawa, K.,Hayashi, H. (deposition date: 2022-03-05, release date: 2022-07-06, Last modification date: 2023-11-29)

• Primary citation: Makino, Y.,Oe, C.,Iwama, K.,Suzuki, S.,Nishiyama, A.,Hasegawa, K.,Okuda, H.,Hirata, K.,Ueno, M.,Kawaji, K.,Sasano, M.,Usui, E.,Hosaka, T.,Yabuki, Y.,Shirouzu, M.,Katsumi, M.,Murayama, K.,Hayashi, H.,Kodama, E.N.; Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.; Commun Biol, 5:619-619, 2022; PubMed: 35739195; DOI: 10.1038/s42003-022-03555-x

Experimental method

X-RAY DIFFRACTION (2.62 Å)