7X5N
Crystal structure of E. faecium SHMT in complex with (+)-SHIN-1 and PLP-Ser
Summary for 7X5N
Entry DOI | 10.2210/pdb7x5n/pdb |
Related | 7V3D |
Descriptor | Serine hydroxymethyltransferase, (4R)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1H-pyrano[2,3-c]pyrazole-5-carbonitrile, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE, ... (4 entities in total) |
Functional Keywords | e. faecium, serine hydroxymethyltransferase, 1c metabolism, transferase |
Biological source | Enterococcus faecium |
Total number of polymer chains | 2 |
Total formula weight | 91483.49 |
Authors | |
Primary citation | Makino, Y.,Oe, C.,Iwama, K.,Suzuki, S.,Nishiyama, A.,Hasegawa, K.,Okuda, H.,Hirata, K.,Ueno, M.,Kawaji, K.,Sasano, M.,Usui, E.,Hosaka, T.,Yabuki, Y.,Shirouzu, M.,Katsumi, M.,Murayama, K.,Hayashi, H.,Kodama, E.N. Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors. Commun Biol, 5:619-619, 2022 Cited by PubMed: 35739195DOI: 10.1038/s42003-022-03555-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report