4UIS
 
 | | The cryoEM structure of human gamma-Secretase complex | | Descriptor: | GAMMA-SECRETASE, LYSOZYME | | Authors: | Sun, L, Zhao, L, Yang, G, Yan, C, Zhou, R, Zhou, X, Xie, T, Zhao, Y, Wu, S, Li, X, Shi, Y. | | Deposit date: | 2015-04-03 | | Release date: | 2015-06-10 | | Last modified: | 2017-08-02 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural Basis of Human Gamma-Secretase Assembly.
Proc.Natl.Acad.Sci.USA, 112, 2015
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8BO2
 | | BAM-EspP complex structure with BamA-S425C/EspP-S1299C mutations in nanodisc | | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | | Authors: | Shen, C, Chang, S, Luo, Q, Zhang, Z, Xie, T, Luo, B, Lu, G, Zhu, X, Wei, X, Dong, C, Zhou, R, Zhang, X, Tang, X, Dong, H. | | Deposit date: | 2022-11-14 | | Release date: | 2023-04-26 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of BAM-mediated outer membrane beta-barrel protein assembly.
Nature, 617, 2023
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8BNZ
 | | BAM-EspP complex structure with BamA-G431C/EspP-N1293C mutations in nanodisc | | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | | Authors: | Shen, C, Chang, S, Luo, Q, Zhang, Z, Xie, T, Luo, B, Lu, G, Zhu, X, Wei, X, Dong, C, Zhou, R, Zhang, X, Tang, X, Dong, H. | | Deposit date: | 2022-11-14 | | Release date: | 2023-04-26 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of BAM-mediated outer membrane beta-barrel protein assembly.
Nature, 617, 2023
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4YVU
 | | Crystal structure of CotA native enzyme in the acid condition, PH5.6 | | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, GLYCEROL, ... | | Authors: | Liu, Z.C, Xie, T, Wang, G.G. | | Deposit date: | 2015-03-20 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of CotA laccase complexed with 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate) at a novel binding site
Acta Crystallogr.,Sect.F, 72, 2016
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4YVN
 | | Crystal structure of CotA laccase complexed with ABTS at a novel binding site | | Descriptor: | 1,2-ETHANEDIOL, 3-ETHYL-2-[(2Z)-2-(3-ETHYL-6-SULFO-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)HYDRAZINO]-6-SULFO-3H-1,3-BENZOTHIAZOL-1-IUM, COPPER (II) ION, ... | | Authors: | Liu, Z.C, Xie, T, Wang, G.G. | | Deposit date: | 2015-03-20 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of CotA laccase complexed with 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate) at a novel binding site
Acta Crystallogr.,Sect.F, 72, 2016
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7Y8C
 | | Crystal structure of CotA laccase complexed with syringaldehyde | | Descriptor: | 3,5-dimethoxy-4-oxidanyl-benzaldehyde, COPPER (II) ION, Spore coat protein A, ... | | Authors: | Liu, Z.C, Xie, T, Wang, G.G. | | Deposit date: | 2022-06-23 | | Release date: | 2023-06-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular insights into substrate promiscuity of CotA laccase catalyzing lignin-phenol derivatives.
Int.J.Biol.Macromol., 256, 2023
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7Y8B
 | | Crystal structure of CotA laccase complexed with syringic acid | | Descriptor: | 3,5-dimethoxy-4-oxidanyl-benzoic acid, COPPER (II) ION, Spore coat protein A, ... | | Authors: | Liu, Z.C, Xie, T, Wang, G.G. | | Deposit date: | 2022-06-23 | | Release date: | 2023-06-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular insights into substrate promiscuity of CotA laccase catalyzing lignin-phenol derivatives.
Int.J.Biol.Macromol., 256, 2023
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2KHS
 | | Solution structure of SNase121:SNase(111-143) complex | | Descriptor: | Nuclease, Thermonuclease | | Authors: | Geng, Y, Feng, Y, Xie, T, Shan, L, Wang, J. | | Deposit date: | 2009-04-10 | | Release date: | 2009-10-20 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The native-like interactions between SNase121 and SNase(111-143) fragments induce the recovery of their native-like structures and the ability to degrade DNA.
Biochemistry, 48, 2009
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2L9S
 | | Solution structure of Pf1 SID1-mSin3A PAH2 Complex | | Descriptor: | PHD finger protein 12, Paired amphipathic helix protein Sin3a | | Authors: | Senthil Kumar, G, Xie, T, Zhang, Y, Radhakrishnan, I. | | Deposit date: | 2011-02-23 | | Release date: | 2011-05-11 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the mSin3A PAH2-Pf1 SID1 Complex: A Mad1/Mxd1-Like Interaction Disrupted by MRG15 in the Rpd3S/Sin3S Complex.
J.Mol.Biol., 408, 2011
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2PQE
 | | Solution structure of proline-free mutant of staphylococcal nuclease | | Descriptor: | Thermonuclease | | Authors: | Shan, L, Tong, Y, Xie, T, Wang, M, Wang, J. | | Deposit date: | 2007-05-01 | | Release date: | 2007-06-19 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease.
Biochemistry, 46, 2007
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6M4O
 | | Cryo-EM structure of the monomeric SPT-ORMDL3 complex | | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | | Deposit date: | 2020-03-08 | | Release date: | 2021-02-10 | | Last modified: | 2021-03-24 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.
Nat.Struct.Mol.Biol., 28, 2021
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6M4N
 | | Cryo-EM structure of the dimeric SPT-ORMDL3 complex | | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | | Deposit date: | 2020-03-07 | | Release date: | 2021-02-10 | | Last modified: | 2021-03-24 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.
Nat.Struct.Mol.Biol., 28, 2021
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7CQI
 | | Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex | | Descriptor: | ORM1-like protein 3, Serine palmitoyltransferase 1, Serine palmitoyltransferase 2, ... | | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | | Deposit date: | 2020-08-11 | | Release date: | 2021-02-10 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.
Nat.Struct.Mol.Biol., 28, 2021
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7CQK
 | | Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex | | Descriptor: | ORM1-like protein 3, Serine palmitoyltransferase 1, Serine palmitoyltransferase 2, ... | | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | | Deposit date: | 2020-08-11 | | Release date: | 2021-02-10 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.
Nat.Struct.Mol.Biol., 28, 2021
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7C6C
 | | Crystal structure of native chitosanase from Bacillus subtilis MY002 | | Descriptor: | (2S)-2-hydroxybutanedioic acid, Chitosanase | | Authors: | Gou, Y, Liu, Z.C, Xie, T, Wang, G.G. | | Deposit date: | 2020-05-21 | | Release date: | 2021-03-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.258 Å) | | Cite: | Structure-based rational design of chitosanase CsnMY002 for high yields of chitobiose.
Colloids Surf B Biointerfaces, 202, 2021
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7C6D
 | | Crystal structure of E19A mutant chitosanase from Bacillus subtilis MY002 complexed with 6 GlcN. | | Descriptor: | 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, Chitosanase | | Authors: | Gou, Y, Liu, Z.C, Xie, T, Wang, G.G. | | Deposit date: | 2020-05-21 | | Release date: | 2021-03-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.451 Å) | | Cite: | Structure-based rational design of chitosanase CsnMY002 for high yields of chitobiose.
Colloids Surf B Biointerfaces, 202, 2021
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1RKN
 | | Solution structure of 1-110 fragment of Staphylococcal Nuclease with G88W mutation | | Descriptor: | Thermonuclease | | Authors: | Liu, D.S, Feng, Y.G, Ye, K.Q, Shan, L, Wang, J.F. | | Deposit date: | 2003-11-22 | | Release date: | 2004-12-07 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Folding stability and cooperativity of the three forms of 1-110 residues fragment of staphylococcal nuclease
Biophys.J., 92, 2007
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7WWB
 | | Choline transporter-like protein 1 | | Descriptor: | CHOLESTEROL, CHOLINE ION, Choline transporter-like protein 1 | | Authors: | Chi, X.M, Zhou, Q. | | Deposit date: | 2022-02-12 | | Release date: | 2022-06-22 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | Rational exploration of fold atlas for human solute carrier proteins.
Structure, 30, 2022
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8SLN
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8SLM
 | | Crystal structure of Deinococcus geothermalis PprI | | Descriptor: | MANGANESE (II) ION, SULFATE ION, Zn dependent hydrolase fused to HTH domain, ... | | Authors: | Zhao, Y, Lu, H. | | Deposit date: | 2023-04-23 | | Release date: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA.
Nat Commun, 15, 2024
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4OBE
 | | Crystal Structure of GDP-bound Human KRas | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D. | | Deposit date: | 2014-01-07 | | Release date: | 2014-06-04 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
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7MXN
 | | PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999 | | Descriptor: | (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | Authors: | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | | Deposit date: | 2021-05-19 | | Release date: | 2021-11-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol.Cancer Ther., 21, 2022
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7MX7
 | | PRMT5:MEP50 complexed with inhibitor PF-06939999 | | Descriptor: | (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | Authors: | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | | Deposit date: | 2021-05-18 | | Release date: | 2021-11-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol.Cancer Ther., 21, 2022
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7MXA
 | | PRMT5:MEP50 complexed with inhibitor PF-06855800 | | Descriptor: | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | Authors: | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | | Deposit date: | 2021-05-18 | | Release date: | 2021-11-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.713 Å) | | Cite: | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol.Cancer Ther., 21, 2022
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7MXC
 | | PRMT5:MEP50 complexed with adenosine | | Descriptor: | ADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | Authors: | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | | Deposit date: | 2021-05-18 | | Release date: | 2021-11-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol.Cancer Ther., 21, 2022
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