5MJ3
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![BU of 5mj3 by Molmil](/molmil-images/mine/5mj3) | INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 1 | Descriptor: | ALPHABODY MA12, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ... | Authors: | Desmet, J, Verstraete, K, Bloch, Y, Lorent, E, Wen, Y, Devreese, B, Vandenbroucke, K, Loverix, S, Hettmann, T, Deroo, S, Somers, K, Hendrikx, P, Lasters, I, Savvides, S.N. | Deposit date: | 2016-11-29 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Structural Basis Of Il-23 Antagonism By An Alphabody Protein Scaffold. Nat Commun, 5, 2014
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3BM9
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![BU of 3bm9 by Molmil](/molmil-images/mine/3bm9) | Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 | Descriptor: | 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol, Heat shock protein HSP 90-alpha | Authors: | Gopalsamy, A, Shi, M, Vogan, E.M, Golas, J, Jacob, J, Johnson, J, Lee, F, Nilakantan, R, Peterson, R, Svenson, K, Tam, M.S, Wen, Y, Chopra, R, Ellingboe, J, Arndt, K, Boschelli, F. | Deposit date: | 2007-12-12 | Release date: | 2008-07-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J.Med.Chem., 51, 2008
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3BMY
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![BU of 3bmy by Molmil](/molmil-images/mine/3bmy) | Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 | Descriptor: | 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol, Heat shock protein HSP 90-alpha | Authors: | Gopalsamy, A, Shi, M, Vogan, E.M, Golas, J, Jacob, J, Johnson, J, Lee, F, Nilakantan, R, Peterson, R, Svenson, K, Tam, M.S, Wen, Y, Chopra, R, Ellingboe, J, Arndt, K, Boschelli, F. | Deposit date: | 2007-12-13 | Release date: | 2008-07-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J.Med.Chem., 51, 2008
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2KDY
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![BU of 2kdy by Molmil](/molmil-images/mine/2kdy) | NMR structure of LP2086-B01 | Descriptor: | Factor H binding protein variant B01_001 | Authors: | Mascioni, A, Bentley, B.E, Camarda, R, Dilts, D.A, Fink, P, Gusarova, V, Hoiseth, S, Jacob, J, Lin, S.L, Malakian, K, McNeil, L.K, Mininni, T, Moy, F, Murphy, E, Novikova, E, Sigethy, S, Wen, Y, Zlotnick, G.W, Tsao, D.H.H. | Deposit date: | 2009-01-20 | Release date: | 2009-02-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086. J.Biol.Chem., 284, 2009
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6NSJ
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![BU of 6nsj by Molmil](/molmil-images/mine/6nsj) | CryoEM structure of Helicobacter pylori urea channel in closed state | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel | Authors: | Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H. | Deposit date: | 2019-01-24 | Release date: | 2019-04-03 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM. Sci Adv, 5, 2019
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6NSK
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![BU of 6nsk by Molmil](/molmil-images/mine/6nsk) | CryoEM structure of Helicobacter pylori urea channel in open state. | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel | Authors: | Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H. | Deposit date: | 2019-01-24 | Release date: | 2019-04-03 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM. Sci Adv, 5, 2019
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2MUX
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![BU of 2mux by Molmil](/molmil-images/mine/2mux) | |
6KCZ
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![BU of 6kcz by Molmil](/molmil-images/mine/6kcz) | |
8IMW
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![BU of 8imw by Molmil](/molmil-images/mine/8imw) | |
7VPG
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![BU of 7vpg by Molmil](/molmil-images/mine/7vpg) | Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 | Descriptor: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | Authors: | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | Deposit date: | 2021-10-17 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export. Front Mol Biosci, 8, 2021
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7VPH
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![BU of 7vph by Molmil](/molmil-images/mine/7vph) | Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 | Descriptor: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | Authors: | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | Deposit date: | 2021-10-17 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export. Front Mol Biosci, 8, 2021
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3G60
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![BU of 3g60 by Molmil](/molmil-images/mine/3g60) | Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | Descriptor: | (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a | Authors: | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | Deposit date: | 2009-02-05 | Release date: | 2009-03-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science, 323, 2009
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3G5U
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![BU of 3g5u by Molmil](/molmil-images/mine/3g5u) | Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | Descriptor: | MERCURY (II) ION, Multidrug resistance protein 1a | Authors: | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | Deposit date: | 2009-02-05 | Release date: | 2009-03-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science, 323, 2009
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3G61
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![BU of 3g61 by Molmil](/molmil-images/mine/3g61) | Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | Descriptor: | (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a | Authors: | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | Deposit date: | 2009-02-05 | Release date: | 2009-03-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.35 Å) | Cite: | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science, 323, 2009
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3P50
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![BU of 3p50 by Molmil](/molmil-images/mine/3p50) | Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC | Descriptor: | 2,6-BIS(1-METHYLETHYL)PHENOL, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Nury, H, Van Renterghem, C, Weng, Y, Tran, A, Baaden, M, Dufresne, V, Changeux, J.P, Sonner, J.M, Delarue, M, Corringer, P.J. | Deposit date: | 2010-10-07 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel Nature, 469, 2011
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3P4W
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![BU of 3p4w by Molmil](/molmil-images/mine/3p4w) | Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC | Descriptor: | (2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Nury, H, Van Renterghem, C, Weng, Y, Tran, A, Baaden, M, Dufresne, V, Changeux, J.P, Sonner, J.M, Delarue, M, Corringer, P.J. | Deposit date: | 2010-10-07 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel Nature, 469, 2011
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2JOH
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![BU of 2joh by Molmil](/molmil-images/mine/2joh) | |
2JOM
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![BU of 2jom by Molmil](/molmil-images/mine/2jom) | |
2FJ3
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![BU of 2fj3 by Molmil](/molmil-images/mine/2fj3) | |
5KZA
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![BU of 5kza by Molmil](/molmil-images/mine/5kza) | Crystal structure of the Rous sarcoma virus matrix protein (aa 2-102). Space group I41 | Descriptor: | 1,2-ETHANEDIOL, NITRATE ION, virus matrix protein | Authors: | Kingston, R.L, Chan, J, Vogt, V.M. | Deposit date: | 2016-07-24 | Release date: | 2017-07-26 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties. Biophys. J., 113, 2017
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5KZ9
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![BU of 5kz9 by Molmil](/molmil-images/mine/5kz9) | |
5KZB
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![BU of 5kzb by Molmil](/molmil-images/mine/5kzb) | |
6VJT
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![BU of 6vjt by Molmil](/molmil-images/mine/6vjt) | |
7V2A
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![BU of 7v2a by Molmil](/molmil-images/mine/7v2a) | SARS-CoV-2 Spike trimer in complex with XG014 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, The heavy chain of XG014, ... | Authors: | Wang, K, Wang, X, Pan, L. | Deposit date: | 2021-08-07 | Release date: | 2021-10-20 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | An ultrapotent pan-beta-coronavirus lineage B ( beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein Cell, 13, 2022
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7V26
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![BU of 7v26 by Molmil](/molmil-images/mine/7v26) | XG005-bound SARS-CoV-2 S | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, XG005 Heavy chain, ... | Authors: | Zhan, W.Q, Zhang, X, Sun, L, Chen, Z.G. | Deposit date: | 2021-08-07 | Release date: | 2021-10-20 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | An ultrapotent pan-beta-coronavirus lineage B ( beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein Cell, 13, 2022
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