2E94
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![BU of 2e94 by Molmil](/molmil-images/mine/2e94) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-364 | Descriptor: | 3-BIPHENYL-3-YL-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION | Authors: | Guo, R.T, Ko, T.P, Cao, R, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-01-24 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E92
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![BU of 2e92 by Molmil](/molmil-images/mine/2e92) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-261 | Descriptor: | (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION | Authors: | Guo, R.T, Ko, T.P, Cao, R, Jeng, W.Y, Chen, C.K.-M, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-01-24 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E8U
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![BU of 2e8u by Molmil](/molmil-images/mine/2e8u) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and IPP (P21) | Descriptor: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION | Authors: | Guo, R.T, Chen, C.K.-M, Ko, T.P, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-01-23 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E91
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![BU of 2e91 by Molmil](/molmil-images/mine/2e91) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-91 | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, ZOLEDRONIC ACID | Authors: | Guo, R.T, Ko, T.P, Cao, R, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-01-24 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E8X
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![BU of 2e8x by Molmil](/molmil-images/mine/2e8x) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GPP | Descriptor: | GERANYL DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION | Authors: | Guo, R.T, Ko, T.P, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-01-24 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E93
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![BU of 2e93 by Molmil](/molmil-images/mine/2e93) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-629 | Descriptor: | Geranylgeranyl pyrophosphate synthetase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID | Authors: | Guo, R.T, Cao, R, Ko, T.P, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-01-24 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E95
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![BU of 2e95 by Molmil](/molmil-images/mine/2e95) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675 | Descriptor: | 1-HYDROXY-2-[3'-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC ACID, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION | Authors: | Guo, R.T, Cao, R, Ko, T.P, Jeng, W.Y, Chang, T.H, Chen, C.K.-M, Liang, P.H, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-01-24 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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4EJT
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![BU of 4ejt by Molmil](/molmil-images/mine/4ejt) | |
4EJU
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![BU of 4eju by Molmil](/molmil-images/mine/4eju) | |
4EM2
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![BU of 4em2 by Molmil](/molmil-images/mine/4em2) | |
4EJW
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![BU of 4ejw by Molmil](/molmil-images/mine/4ejw) | |
4EM0
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![BU of 4em0 by Molmil](/molmil-images/mine/4em0) | |
4EM1
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![BU of 4em1 by Molmil](/molmil-images/mine/4em1) | |
4EJV
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![BU of 4ejv by Molmil](/molmil-images/mine/4ejv) | Staphylococcus epidermidis TcaR in complex with chloramphenicol | Descriptor: | 2,2-dichloro-N-[(1S,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide, Transcriptional regulator TcaR | Authors: | Chang, Y.M, Chen, C.K.M, Wang, A.H.J. | Deposit date: | 2012-04-07 | Release date: | 2013-05-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural analysis of the antibiotic recognition mechanism of MarR family proteins Acta Crystallogr.,Sect.D, 2013
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2W0B
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![BU of 2w0b by Molmil](/molmil-images/mine/2w0b) | |
3UE5
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![BU of 3ue5 by Molmil](/molmil-images/mine/3ue5) | ECP-cleaved Actin in complex with Spir domain D | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Chen, C, Phillips, M, Sawaya, M.R, Ralston, C.Y, Quinlan, M.E. | Deposit date: | 2011-10-28 | Release date: | 2012-02-15 | Last modified: | 2012-04-11 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Multiple Forms of Spire-Actin Complexes and their Functional Consequences. J.Biol.Chem., 287, 2012
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4EFH
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![BU of 4efh by Molmil](/molmil-images/mine/4efh) | Acanthamoeba Actin complex with Spir domain D | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-1, CALCIUM ION, ... | Authors: | Chen, C, Phillips, M, Sawaya, M.R, Quinlan, M.E. | Deposit date: | 2012-03-29 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Multiple Forms of Spire-Actin Complexes and their Functional Consequences. J.Biol.Chem., 287, 2012
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3C7K
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![BU of 3c7k by Molmil](/molmil-images/mine/3c7k) | Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(o) subunit alpha, MAGNESIUM ION, ... | Authors: | Slep, K.C, Kercher, M.A, Wieland, T, Chen, C, Simon, M.I, Sigler, P.B. | Deposit date: | 2008-02-07 | Release date: | 2008-05-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3C7L
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![BU of 3c7l by Molmil](/molmil-images/mine/3c7l) | Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation | Descriptor: | Regulator of G-protein signaling 16 | Authors: | Slep, K.C, Kercher, M.A, Wieland, T, Chen, C, Simon, M.I, Sigler, P.B. | Deposit date: | 2008-02-07 | Release date: | 2008-05-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2P1C
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![BU of 2p1c by Molmil](/molmil-images/mine/2p1c) | T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-210 | Descriptor: | ACETATE ION, BETA-MERCAPTOETHANOL, Farnesyl pyrophosphate synthase, ... | Authors: | Cao, R, Gao, Y, Oldfield, E. | Deposit date: | 2007-03-04 | Release date: | 2008-03-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Proteins, 73, 2008
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3UX4
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![BU of 3ux4 by Molmil](/molmil-images/mine/3ux4) | |
4YP1
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![BU of 4yp1 by Molmil](/molmil-images/mine/4yp1) | Misting with CDA | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein | Authors: | Chin, K.H, Chen, C.K, Tu, Z.I, Chou, S.H. | Deposit date: | 2015-03-12 | Release date: | 2015-10-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK. Biochemistry, 54, 2015
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5AEL
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![BU of 5ael by Molmil](/molmil-images/mine/5ael) | T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597 | Descriptor: | FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate) | Authors: | Yang, G, Oldfield, E, No, J.H. | Deposit date: | 2014-12-26 | Release date: | 2015-10-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
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2ZEU
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![BU of 2zeu by Molmil](/molmil-images/mine/2zeu) | S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with BPH-715 | Descriptor: | 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, Geranylgeranyl pyrophosphate synthetase | Authors: | Guo, R.T, Chen, C.K.-M, Cao, R, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-12-17 | Release date: | 2008-12-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation J.Am.Chem.Soc., 131, 2009
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2ZEV
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![BU of 2zev by Molmil](/molmil-images/mine/2zev) | S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium, IPP and BPH-715 | Descriptor: | 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, ... | Authors: | Guo, R.T, Chen, C.K.-M, Cao, R, Oldfield, E, Wang, A.H.-J. | Deposit date: | 2007-12-17 | Release date: | 2008-12-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation J.Am.Chem.Soc., 131, 2009
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