2E95

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675

Summary for 2E95

• Entry DOI: 10.2210/pdb2e95/pdb
• Related: 2DH4 2E8T 2E8U 2E8V 2E8W 2E8X 2E90 2E91 2E92 2E93 2E94 2E96 2E97
• Descriptor: Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 1-HYDROXY-2-[3'-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC ACID, ... (4 entities in total)
• Functional Keywords: prenyltransferase, farnesyl pyrophosphate, bisphosphonate, transferase
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Cytoplasm (By similarity): Q12051
• Total number of polymer chains: 2
• Total formula weight: 79822.24

Authors

Guo, R.T.,Cao, R.,Ko, T.P.,Jeng, W.Y.,Chang, T.H.,Chen, C.K.-M.,Liang, P.H.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-01-24, release date: 2007-06-12, Last modification date: 2023-10-25)

• Primary citation: Guo, R.T.,Cao, R.,Liang, P.H.,Ko, T.P.,Chang, T.H.,Hudock, M.P.,Jeng, W.Y.,Chen, C.K.-M.,Zhang, Y.,Song, Y.,Kuo, C.J.,Yin, F.,Oldfield, E.,Wang, A.H.-J.; Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases; Proc.Natl.Acad.Sci.Usa, 104:10022-10027, 2007; PubMed: 17535895; DOI: 10.1073/pnas.0702254104

Experimental method

X-RAY DIFFRACTION (2.2 Å)