S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium, IPP and BPH-715

Summary for 2ZEV

Related2DH4 2E8T 2E8U 2E8V 2E8W 2E8X 2E90 2E91 2E92 2E93 2E94 2E95 2ZEU
DescriptorGeranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, ... (5 entities in total)
Functional Keywordsprenyltransferase, farnesyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm (By similarity) Q12051
Total number of polymer chains2
Total molecular weight79790.2
Guo, R.T.,Chen, C.K.-M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-12-17, release date: 2008-12-23, Last modification date: 2011-07-13)
Primary citation
Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.-G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.-K.,Lin, F.-Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.-J.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E.
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
J.Am.Chem.Soc., 131:5153-5162, 2009
PubMed: 19309137 (PDB entries with the same primary citation)
DOI: 10.1021/ja808285e
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25116 0.9% 3.2% 3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21